Results 31 to 40 of about 1,359,813 (255)

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Drilling down hotspots of infraspecific diversity to bring them into on-ground conservation of threatened species [PDF]

, 2019
Unprecedented rates of biodiversity loss raise the urgency for preserving species ability to cope with ongoing global changes. An approach in this direction is to target intra-specific hotspots of genetic diversity as conservation priorities.
Aloise, Gaetano, Bisconti, Roberta, Canestrelli, Daniele, Chiocchio, Andrea, MAIORANO, Luigi, Martino, Chiara, Martino, Giuseppe, Nascetti, Giuseppe, Pellegrino, Francesco, Pezzarossa, Alice, Siclari, Antonino, Zampiglia, Mauro   +11 more
core   +2 more sources

Genetic diversity, inbreeding and cancer [PDF]

Proceedings of the Royal Society B: Biological Sciences, 2018
Genetic diversity is essential for adaptive capacities, providing organisms with the potential of successfully responding to intrinsic and extrinsic challenges. Although a clear reciprocal link between genetic diversity and resistance to parasites and pathogens has been established across taxa, the impact of loss of genetic diversity by inbreeding on ...
Beata Ujvari, Nynke Raven, Tracey Russell, Frédéric Thomas, Rodrigo Hamede, Rodrigo Hamede, Marion Vittecoq, Marcel Klaassen, Thomas Madsen   +8 more
openaire   +5 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

The effect of multiple paternity on genetic diversity during and after colonisation [PDF]

, 2012
In metapopulations, genetic variation of local populations is influenced by the genetic content of the founders, and of migrants following establishment.
André, C., Charrier, G., Eriksson, A., Johannesson, K., Mehlig, B., Panova, M., Rafajlovic, M., Rimark, A., Saltin, S. H.   +8 more
core   +4 more sources

Genetic Diversity in Weeds [PDF]

, 2012
Weeds growing in cultivated areas are usually characterized as having high phenotype plasticity and genetic adaptability. They are frequently well-adapted to disturbance and often seed prolifically (Adahl et al., 2006). Thus, improving the current knowledge on the genetic diversity of weed populations is a challenge for management, primarily because ...
Rubem Silvério de Oliveira Júnior, Maria de Fátima P.S. Machado, Claudete Aparecida Mangolin   +2 more
openaire   +3 more sources

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Developing know-how for the improvement and sustainable management of teak genetic resources [PDF]

, 2008
The project had the following objectives: To trace and quantify genetic diversity of teak within its natural range, DNA markers were used to assay the current distribution of genetic diversity within and between populations, investigate its mating ...
Cavers, Stephen, Davies, Samantha, Lowe, Andrew, Puthanveettil, Indira, Sudarsono, S., Van Der Straeten, Dominique, Vanavichit, Apichart, Volkaert, Hugo, Wellendorf, Hubert   +8 more
core  

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Multilocus sequence analysis of xanthomonads causing bacterial spot of tomato and pepper plants reveals strains generated by recombination among species and recent global spread of Xanthomonas gardneri [PDF]

, 2015
Four Xanthomonas species are known to cause bacterial spot of tomato and pepper, but the global distribution and genetic diversity of these species are not well understood.
Bart, Rebecca, Boyer, Claudine, Goss, Erica, Jibrin, Mustafa O., Jones, Jeffrey R., Kebede, Misrak, Minsavage, Gerald V., Potnis, Neha, Pruvost, Olivier, Schwartz, Allison, Staskawicz, Brian, Timilsina, Sujan, Vallad, Gary E.   +12 more
core   +1 more source