Results 41 to 50 of about 641,007 (266)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Genetic progress in rice yield: preliminary insights from historically released varieties in Sub-Saharan Africa

Frontiers in Plant Science
Rice is a vital staple crop in sub-Saharan Africa (SSA), where improving grain yield is critical for food security and economic growth. Assessing genetic gain over time is essential for measuring breeding effectiveness and guiding future strategies and ...
Shailesh Yadav, Vimal Kumar Semwal, Gbènakpon Aubin Y. G. Amagnide, Esther Pegalepo, Kora Orou Kobi, Kossi Lorimpo Adjah, Nana Kofi Abaka Amoah, Raafat El-Namaky, Negussie Zenna, Epa N’da Ghislain Noumouha, Faye Omar Ndaw, Muhammad Liman Muhammad, Laho Mamadou Barry, Medoune Khouma, Dolo Menidiou, Dule Zhao, Baboucarr Manneh   +16 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Cross-species optimization of nuclei isolation in ten plant species

Plant Methods
Single-cell technologies are transforming plant biology, yet broadly transferable nuclei isolation remains a key bottleneck for snRNA-seq. We developed a reproducible, cost-efficient Percoll-based workflow that is applicable to multiple maize tissues and
Yun Luo, Jiali Yan, Thuy La, Edward S. Buckler, Jianbing Yan, M. Cinta Romay   +5 more
doaj   +1 more source

Unraveling the meiotic puzzle: chromosome count, meiotic behaviour, and reproductive challenges in Phlomis cashmeriana Royle ex Benth. from the Kashmir Himalaya

Frontiers in Conservation Science
Meiotic stability is crucial for maintaining reproductive success and genetic diversity in plants, especially in montane regions like the Himalaya, where fluctuating environmental conditions can disrupt normal chromosome behavior.
Roof Ul Qadir, Hanan Javid, Aijaz Hassan Ganie, Bilal A. Wani, Irshad A. Nawchoo, Junaid A. Magray   +5 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Untangling the reproductive puzzle: how floral traits, pollinator behavior, and breeding strategy shape reproductive success in the Himalayan medicinal herb Phytolacca acinosa Roxb

Frontiers in Plant Science
Understanding the reproductive ecology of plants is crucial for devising strategies for their sustainable utilization and effective conservation.
Junaid A. Magray, Bilal A. Wani, Irshad A. Nawchoo, Aijaz H. Ganie, Hanan Javid, Roof Ul Qadir   +5 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source