Results 1 to 10 of about 5,538,595 (306)

Conjugated Polymeric Materials in Biological Imaging and Cancer Therapy

open access: yesMolecules, 2023
Conjugated polymers (CPs) have attracted much attention in the fields of chemistry, medicine, life science, and material science. Researchers have carried out a series of innovative researches and have made significant research progress regarding the ...
Qinbin Zheng   +7 more
doaj   +1 more source

Copper Imbalance in Alzheimer’s Disease: Meta-Analysis of Serum, Plasma, and Brain Specimens, and Replication Study Evaluating ATP7B Gene Variants

open access: yesBiomolecules, 2021
Evidence indicates that patients with Alzheimer’s dementia (AD) show signs of copper (Cu) dyshomeostasis. This study aimed at evaluating the potential of Cu dysregulation as an AD susceptibility factor.
Rosanna Squitti   +13 more
doaj   +1 more source

Loss of Neuroprotective Factors in Neurodegenerative Dementias: The End or the Starting Point?

open access: yesFrontiers in Neuroscience, 2017
Recent clinical, genetic and biochemical experimental evidences highlight the existence of common molecular pathways underlying neurodegenerative diseases.
Luisa Benussi   +3 more
doaj   +1 more source

Prodromal frontotemporal dementia: clinical features and predictors of progression

open access: yesAlzheimer’s Research & Therapy, 2021
Background The prodromal phase of frontotemporal dementia (FTD) is still not well characterized, and conversion rates to dementia and predictors of progression at 1-year follow-up are currently unknown.
Alberto Benussi   +9 more
doaj   +1 more source

Reduced Intensity Conditioning for Allogeneic Stem Cell Transplantation (HSCT) in Acute Myeloid Leukemia

open access: yesHematology, Transfusion and Cell Therapy, 2022
Allogeneic transplantation (HSCT) is an effective curative therapy for high risk acute myeloid leukemia (AML) which account for 38% of the transplants in Europe (1). Prior to HSCT, a conditioning or preparative regimen is administered.
Arnon Nagler
doaj   +1 more source

High-Throughput Sequencing Strategy for Microsatellite Genotyping Using Neotropical Fish as a Model

open access: yesFrontiers in Genetics, 2018
Genetic diversity and population studies are essential for conservation and wildlife management programs. However, monitoring requires the analysis of multiple loci from many samples. These processes can be laborious and expensive.
Juliana S. M. Pimentel   +9 more
doaj   +1 more source

Genetic counselling and testing for inherited dementia: single-centre evaluation of the consensus Italian DIAfN protocol

open access: yesAlzheimer’s Research & Therapy, 2020
Background A consensus protocol for genetic counselling and testing of familial dementia, the Italian Dominantly Inherited Alzheimer’s and Frontotemporal Network (IT-DIAfN) protocol, has been developed in Italy by a network of expert dementia centres ...
Anna Mega   +9 more
doaj   +1 more source

Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer’s disease

open access: yesActa Neuropathologica Communications, 2018
One of the earliest pathological features characterizing Alzheimer’s disease (AD) is the loss of dendritic spines. Among the many factors potentially mediating this loss of neuronal connectivity, the contribution of Rho-GTPases is of particular interest.
Mirta Borin   +15 more
doaj   +1 more source

No added diagnostic value of non-phosphorylated tau fraction (p-taurel) in CSF as a biomarker for differential dementia diagnosis

open access: yesAlzheimer’s Research & Therapy, 2017
Background The Alzheimer’s disease (AD) cerebrospinal fluid (CSF) biomarkers Aβ1–42, t-tau, and p-tau181 overlap with other diseases. New tau modifications or epitopes, such as the non-phosphorylated tau fraction (p-taurel), may improve differential ...
Joery Goossens   +15 more
doaj   +1 more source

Complete mitochondrial genomes from three species of the genus Peckia (Sarcophagidae) with forensic entomology interest

open access: yesMitochondrial DNA. Part B. Resources, 2019
Peckia is one of the most important genera in the Sarcophagidae family of flesh flies. This genus is distributed in Brazil and Latin America, and its species can be used to estimate the Post Mortem Interval (PMI) in forensic investigations.
Susanne Faccin   +5 more
doaj   +1 more source

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