Results 1 to 10 of about 2,144,828 (297)

Amyloid-β1–43 cerebrospinal fluid levels and the interpretation of APP, PSEN1 and PSEN2 mutations

Alzheimer’s Research & Therapy, 2020
Background Alzheimer’s disease (AD) mutations in amyloid precursor protein (APP) and presenilins (PSENs) could potentially lead to the production of longer amyloidogenic Aβ peptides. Amongst these, Aβ1–43 is more prone to aggregation and has higher toxic
Federica Perrone, Maria Bjerke, Elisabeth Hens, Anne Sieben, Maarten Timmers, Arne De Roeck, Rik Vandenberghe, Kristel Sleegers, Jean-Jacques Martin, Peter P. De Deyn, Sebastiaan Engelborghs, Julie van der Zee, Christine Van Broeckhoven, Rita Cacace, on behalf of the BELNEU Consortium   +14 more
doaj   +1 more source

Transferability of SSR markers from Eugenia uniflora L. to Myrtaceae species of the Atlantic Forest

Acta Botânica Brasílica, 2023
The Myrtaceae family is home to several species of economic and ecological importance, but many are in areas of constant environmental degradation, demanding studies aiming at the conservation status evaluation or other characteristics of interest.
Dalvan Carlos Beise, Luana Oliveira de Oliveira, Daniele Damian dos Santos, Rafael Plá Matielo Lemos, Cristiane D’ Oliveira Matielo, Renata Machado Castro, Valdir Marcos Stefenon   +6 more
doaj   +1 more source

A comprehensive analysis of candidate genes in familial pancreatic cancer families reveals a high frequency of potentially pathogenic germline variants

EBioMedicine, 2020
Background: The 5-year survival rate of patients with pancreatic ductal adenocarcinoma (PDAC) is around 5% due to the fact that the majority of patients present with advanced disease that is treatment resistant. Familial pancreatic cancer (FPC) is a rare
Julie Earl, Cristina Galindo-Pumariño, Jessica Encinas, Emma Barreto, Maria E. Castillo, Vanessa Pachón, Reyes Ferreiro, Mercedes Rodríguez-Garrote, Silvia González-Martínez, Teresa Ramon y Cajal, Luis Robles Diaz, Isabel Chirivella-Gonzalez, Montse Rodriguez, Eva Martínez de Castro, David García-Seisdedos, Gloria Muñoz, Juan Manuel Rosa Rosa, Mirari Marquez, Nuría Malats, Alfredo Carrato   +19 more
doaj   +1 more source

Molecular markers for DNA-fingerprinting in cotton [PDF]

, 2004
Molecular markers are long proposed as suitable for fingerprinting of crop species. With the development of the techniques the attention has shifted from protein to DNA-based markers as age-, tissue- and status-independent and, therefore, more reliable ...
Bojinov, B., Lacape, Jean-Marc
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Molecular Detection of Codon 12 K-RAS Mutations in Circulating DNA from Serum of Colorectal Cancer Patients

The International Journal of Biological Markers, 2000
Point mutations of the K-RAS gene at codon 12 are found in about 40% of cases with colorectal cancer. The diagnostic implications of the detection of these mutations and their clinical utility are still unclear. The aim of this study was to test both the
C. Salbe, C. Trevisiol, E. Ferruzzi, T. Mancuso, R. Nascimbeni, F. Di Fabio, B. Salerni, R. Dittadi   +7 more
doaj   +1 more source

Variable number of tandem repeat markers in the genome sequence of Mycosphaerella fijiensis, the causal agent of black leaf streak disease of banana (Musa spp) [PDF]

, 2010
. We searched the genome of Mycosphaerella fijiensis for molecular markers that would allow population genetics analysis of this plant pathogen. M. fijiensis, the causal agent of banana leaf streak disease, also known as black Sigatoka, is the most ...
Ferreira, C.F., Garcia, S.A.L., Goodwin, S.B., Guzmán, M., Kema, G.H.J., Lee, T.A.J., van der, Lintel Hekkert, B., te, Souza, M.T., Zapater, M.F.   +8 more
core   +4 more sources

Contribution of pks+ Escherichia coli (E. coli) to Colon Carcinogenesis

Microorganisms
Colorectal cancer (CRC) stands as a significant global health concern, ranking second in mortality and third in frequency among cancers worldwide. While only a small fraction of CRC cases can be attributed to inherited genetic mutations, the majority ...
Mohammad Sadeghi, Denis Mestivier, Iradj Sobhani   +2 more
doaj   +1 more source

An Unusual Case of Gullo’s Syndrome Concomitant with Serious Endometriosis Disease in a Postmenopausal Woman

Case Reports in Medicine, 2018
Gullo’s syndrome is a singular physiological phenomenon defined by an abnormal increase in serum pancreatic enzyme levels that may occur in healthy subjects in the absence of pancreatic disorders.
Abdelhakim Ainahi, Abdellaziz Ziane, Lahcen Wakrim, Naima Elmdaghri, Abdelhamid Barakat   +4 more
doaj   +1 more source

Association of short-term cognitive decline and MCI-to-AD dementia conversion with CSF, MRI, amyloid- and 18F-FDG-PET imaging

NeuroImage: Clinical, 2019
Disease-modifying treatment trials are increasingly advanced to the prodromal or preclinical phase of Alzheimer's disease (AD), and inclusion criteria are based on biomarkers rather than clinical symptoms.
Julie Ottoy, Ellis Niemantsverdriet, Jeroen Verhaeghe, Ellen De Roeck, Hanne Struyfs, Charisse Somers, Leonie wyffels, Sarah Ceyssens, Sara Van Mossevelde, Tobi Van den Bossche, Christine Van Broeckhoven, Annemie Ribbens, Maria Bjerke, Sigrid Stroobants, Sebastiaan Engelborghs, Steven Staelens   +15 more
doaj   +1 more source

Integration of microsatellite (SSR) markers in Hevea spp. reference genetic map : a powerful tool for genetic analysis of qualitative and quantitative agronomic traits [PDF]

, 2008
In 2000, was published (Lespinasse et al. 2000) the 1st genetic map of rubber tree (Hevea spp.). This saturated map encompassed 717 loci, allowing an efficient coverage of the 18 chromosomes of the Hevea genome, and it can be considered as the reference ...
Fouet, Olivier, Rodier-Goud, Marguerite, Seguin, Marc, Weber, Christelle   +3 more
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