Results 11 to 20 of about 2,144,828 (297)

Plasma Extracellular Vesicle Size and Concentration Are Altered in Alzheimer’s Disease, Dementia With Lewy Bodies, and Frontotemporal Dementia

Frontiers in Cell and Developmental Biology, 2021
Alzheimer’s disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB) are the three major neurodegenerative dementias. In this study, we provide evidence that an alteration in extracellular vesicles (EVs) release is common across ...
Antonio Longobardi, Luisa Benussi, Roland Nicsanu, Sonia Bellini, Clarissa Ferrari, Claudia Saraceno, Roberta Zanardini, Marcella Catania, Giuseppe Di Fede, Rosanna Squitti, Giuliano Binetti, Giuliano Binetti, Roberta Ghidoni   +12 more
doaj   +1 more source

N-Terminally Truncated and Pyroglutamate-Modified Aβ Forms Are Measurable in Human Cerebrospinal Fluid and Are Potential Markers of Disease Progression in Alzheimer’s Disease

Frontiers in Neuroscience, 2021
Alzheimer’s disease (AD) is a pathology characterized by the accumulation in the brain of intracellular and extracellular amyloid-β (Aβ) aggregates, especially of Aβ1–40 and Aβ1–42 peptides.
Guido Domingo, Luisa Benussi, Claudia Saraceno, Michela Bertuzzi, Roland Nicsanu, Antonio Longobardi, Sonia Bellini, Alfredo Cagnotto, Mario Salmona, Giuliano Binetti, Giuliano Binetti, Roberta Ghidoni   +11 more
doaj   +1 more source

Cerebrospinal Fluid EV Concentration and Size Are Altered in Alzheimer’s Disease and Dementia with Lewy Bodies

Cells, 2022
Alzheimer’s disease (AD), dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD) represent the three major neurodegenerative dementias characterized by abnormal brain protein accumulation. In this study, we investigated extracellular vesicles (
Antonio Longobardi, Roland Nicsanu, Sonia Bellini, Rosanna Squitti, Marcella Catania, Pietro Tiraboschi, Claudia Saraceno, Clarissa Ferrari, Roberta Zanardini, Giuliano Binetti, Giuseppe Di Fede, Luisa Benussi, Roberta Ghidoni   +12 more
doaj   +1 more source

Molecular Markers for Atherosclerosis [PDF]

European Journal of Cardiovascular Prevention & Rehabilitation, 1997
Although cardiovascular disease remains the leading cause of morbidity and mortality in both men and women of all racial groups in the United States, recent clinical trials clearly show that treatment of risk factors such as hyperlipidemia reduces both morbidity and mortality from cardiovascular disease [1].
C M, Ballantyne, Y, Abe
openaire   +2 more sources

Ultrasounds in cancer therapy: A summary of their use and unexplored potential

Oncology Reviews, 2022
Ultrasounds (US) are a non-ionizing mechanical wave, with less adverse effects than conventional pharmacological or surgical treatments. Different biological effects are induced in tissues and cells by ultrasound actuation depending on acoustic ...
Jesús Frutos Díaz-Alejo, Iciar Gonzalez Gomez, Julie Earl   +2 more
doaj   +1 more source

Plasma Small Extracellular Vesicles with Complement Alterations in GRN/C9orf72 and Sporadic Frontotemporal Lobar Degeneration

Cells, 2022
Cutting-edge research suggests endosomal/immune dysregulation in GRN/C9orf72-associated frontotemporal lobar degeneration (FTLD). In this retrospective study, we investigated plasma small extracellular vesicles (sEVs) and complement proteins in 172 ...
Sonia Bellini, Claudia Saraceno, Luisa Benussi, Rosanna Squitti, Sara Cimini, Martina Ricci, Laura Canafoglia, Cinzia Coppola, Gianfranco Puoti, Clarissa Ferrari, Antonio Longobardi, Roland Nicsanu, Marta Lombardi, Giulia D’Arrigo, Claudia Verderio, Giuliano Binetti, Giacomina Rossi, Roberta Ghidoni   +17 more
doaj   +1 more source

Effect of Fragmented DNA From Plant Pathogens on the Protection Against Wilt and Root Rot of Capsicum annuum L. Plants

Frontiers in Plant Science, 2021
Chili pepper (Capsicum annuum L.) production is affected by wilt and root rot, the most devastating disease caused by the pathogen complex of oomycete Phytophthora capsici Leon and the fungi Fusarium oxysporum Schlecht and Rhizoctonia solani Kühn ...
Luz Maria Serrano-Jamaica, Emiliano Villordo-Pineda, Mario Martín González-Chavira, Ramón Gerardo Guevara-González, Gabriela Medina-Ramos   +4 more
doaj   +1 more source

Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder [PDF]

, 2020
Autism Spectrum Disorder (ASD) is one of the most common neurodevelopmental disorders with no drugs treating the core symptoms and no validated biomarkers for clinical use.
Connors, Susan L., Diggins, Eileen, Dinkova-Kostova, Albena, Fahey, Jed W., Liu, Hua, Singh, Kanwaljit, Stephenson, Katherine K., Zimmerman, Andrew W.   +7 more
core   +3 more sources

RRM1 and ERCC1 as biomarkers in patients with locally advanced and metastatic malignant pleural mesothelioma treated with continuous infusion of low-dose gemcitabine plus cisplatin

BMC Cancer, 2021
Background Malignant Pleural Mesothelioma (MPM) is a rare but aggressive neoplasia that usually presents at advanced stages. Even though some advances have been achieved in the management of patients with MPM, this malignancy continuous to impose a ...
Wendy Muñoz-Montaño, Sae Muñiz-Hernández, Alejandro Avilés-Salas, Rodrigo Catalán, Luis Lara-Mejía, Suraj Samtani-Bassarmal, Andres F. Cardona, Jorge Mendoza-Desión, Daniel Hernández-Cueto, Altagracia Maldonado, Guillermina Baay-Guzmán, Sara Huerta-Yepes, Oscar Arrieta   +12 more
doaj   +1 more source

Use of genetic markers for the detection of off-types for DUS phenotypic traits in the inbreeding crop, barley [PDF]

, 2020
Detection of crop off-types is of interest for multiple uses, including the assessment of uniformity for new plant variety applications during distinctness, uniformity and stability (DUS) testing for the awarding of plant breeders’ rights (PBR). Here,
Cockram, James, Donal O'Sullivan, O'Sullivan, Donal M., Saccomanno, Benedetta, Wallace, Margaret   +4 more
core   +1 more source