Results 31 to 40 of about 1,319,694 (261)

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille, Hugo Roux, Odile Fenneteau, Aurélie Caye‐Eude, Alexia Kinoo, Yoann Vial, André Baruchel, Marion Strullu, Elodie Lainey, Hélène Cavé   +9 more
wiley   +1 more source

Molecular Detection of Codon 12 K-RAS Mutations in Circulating DNA from Serum of Colorectal Cancer Patients

The International Journal of Biological Markers, 2000
Point mutations of the K-RAS gene at codon 12 are found in about 40% of cases with colorectal cancer. The diagnostic implications of the detection of these mutations and their clinical utility are still unclear. The aim of this study was to test both the
C. Salbe, C. Trevisiol, E. Ferruzzi, T. Mancuso, R. Nascimbeni, F. Di Fabio, B. Salerni, R. Dittadi   +7 more
doaj   +1 more source

A comprehensive analysis of candidate genes in familial pancreatic cancer families reveals a high frequency of potentially pathogenic germline variants

EBioMedicine, 2020
Background: The 5-year survival rate of patients with pancreatic ductal adenocarcinoma (PDAC) is around 5% due to the fact that the majority of patients present with advanced disease that is treatment resistant. Familial pancreatic cancer (FPC) is a rare
Julie Earl, Cristina Galindo-Pumariño, Jessica Encinas, Emma Barreto, Maria E. Castillo, Vanessa Pachón, Reyes Ferreiro, Mercedes Rodríguez-Garrote, Silvia González-Martínez, Teresa Ramon y Cajal, Luis Robles Diaz, Isabel Chirivella-Gonzalez, Montse Rodriguez, Eva Martínez de Castro, David García-Seisdedos, Gloria Muñoz, Juan Manuel Rosa Rosa, Mirari Marquez, Nuría Malats, Alfredo Carrato   +19 more
doaj   +1 more source

Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger, Efrat Bar‐Ilan, Victoria Marcu, Evgeny Grishin, Rinat Yacobi, Aviv Barzilai, Hana Golan, Assaf Arie Barg   +7 more
wiley   +1 more source

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

Contribution of pks+ Escherichia coli (E. coli) to Colon Carcinogenesis

Microorganisms
Colorectal cancer (CRC) stands as a significant global health concern, ranking second in mortality and third in frequency among cancers worldwide. While only a small fraction of CRC cases can be attributed to inherited genetic mutations, the majority ...
Mohammad Sadeghi, Denis Mestivier, Iradj Sobhani   +2 more
doaj   +1 more source

An Unusual Case of Gullo’s Syndrome Concomitant with Serious Endometriosis Disease in a Postmenopausal Woman

Case Reports in Medicine, 2018
Gullo’s syndrome is a singular physiological phenomenon defined by an abnormal increase in serum pancreatic enzyme levels that may occur in healthy subjects in the absence of pancreatic disorders.
Abdelhakim Ainahi, Abdellaziz Ziane, Lahcen Wakrim, Naima Elmdaghri, Abdelhamid Barakat   +4 more
doaj   +1 more source

Association of short-term cognitive decline and MCI-to-AD dementia conversion with CSF, MRI, amyloid- and 18F-FDG-PET imaging

NeuroImage: Clinical, 2019
Disease-modifying treatment trials are increasingly advanced to the prodromal or preclinical phase of Alzheimer's disease (AD), and inclusion criteria are based on biomarkers rather than clinical symptoms.
Julie Ottoy, Ellis Niemantsverdriet, Jeroen Verhaeghe, Ellen De Roeck, Hanne Struyfs, Charisse Somers, Leonie wyffels, Sarah Ceyssens, Sara Van Mossevelde, Tobi Van den Bossche, Christine Van Broeckhoven, Annemie Ribbens, Maria Bjerke, Sigrid Stroobants, Sebastiaan Engelborghs, Steven Staelens   +15 more
doaj   +1 more source

Molecular markers for prostate cancer [PDF]

Cancer Letters, 2007
Serum PSA testing has been used for over 20 years as an aid in the diagnosis and management of prostate cancer. Although highly sensitive, it suffers from a lack of specificity, showing elevated serum levels in a variety of other conditions including prostatitis, benign prostate hyperplasia, and non-cancerous neoplasia.
Reynolds, M.A., Kastury, K., Groskopf, J., Schalken, J.A., Rittenhouse, H.G.   +4 more
openaire   +3 more sources

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source