Results 101 to 110 of about 5,820,249 (380)
Efforts and Challenges in Engineering the Genetic Code
Life, 2017 This year marks the 48th anniversary of Francis Crick’s seminal work on the origin of the genetic code, in which he first proposed the “frozen accident” hypothesis to describe evolutionary selection against changes to the genetic code that cause ...
Xiao Lin +2 more
doaj +1 more source
The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity
FEBS Letters, EarlyView.The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley +1 more source
Futurenatural? A future of science through the lens of wisdom [PDF]
, 1999 This is a PDF version of an article published in Heythrop Journal© 1999. The definitive version is available at www.blackwell-synergy.com.This article discusses genetic engineering and Christian theories of wisdom, particularly in relation in creation ...
Deane-Drummond, Celia
core
Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin-Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia [PDF]
, 2018 Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a familial arrhythmogenic syndrome characterized by sudden death. There are several genetic forms of CPVT associated with mutations in genes encoding the cardiac ryanodine receptor (RyR2 ...
Belevych, Andriy E +12 more
core +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Genetic Optimization Algorithm for Metabolic Engineering Revisited [PDF]
, 2018 Tobias B. Alter +2 more
openalex +3 more sources
Improved Quantum Genetic Algorithm in Application of Scheduling Engineering Personnel
Abstract and Applied Analysis, 2014 To verify the availability of the improved quantum genetic algorithm in solving the scheduling engineering personnel problem, the following work has been carried out: the characteristics of the scheduling engineering personnel problem are analyzed, the ...
Huaixiao Wang +4 more
doaj +1 more source
System optimization by multiobjective genetic algorithms and analysis of the coupling between variables, constraints and objectives [PDF]
, 2005 This paper presents a methodology based on Multiobjective Genetic Algorithms (MOGA’s) for the design of electrical engineering systems. MOGA’s allow to optimize multiple heterogeneous criteria in complex systems, but also simplify couplings and ...
Roboam, Xavier +2 more
core +2 more sources
Revista de saude publica, 1991 This paper deals with the progress made in genetic engineering techniques, capable of altering the genetic potential of an organism, either by the introduction or the suppression of new structural genes. Some of the general applications are described as are also, more particularly, their uses in the field of medicine.
openaire +2 more sources
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source