Results 101 to 110 of about 1,062,704 (335)

Embryos as Patients? Medical Provider Duties in the Age of CRISPR/Cas9 [PDF]

, 2017
The CRISPR/Cas9 genome engineering platform is the first method of gene editing that could potentially be used to treat genetic disorders in human embryos. No past therapies, genetic or otherwise, have been intended or used to treat disorders in existent
Powell, G. Edward, III
core   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Human Genetic Engineering: A Survey of Student Value Stances [PDF]

, 1975
Sara McCormack Wilson, Thomas R. Mertens, Jon R. Hendrix   +2 more
openalex   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

Metabolic Engineering of Oleaginous Yeasts for Production of Fuels and Chemicals

Frontiers in Microbiology, 2017
Oleaginous yeasts have been increasingly explored for production of chemicals and fuels via metabolic engineering. Particularly, there is a growing interest in using oleaginous yeasts for the synthesis of lipid-related products due to their high ...
Shuobo Shi, Shuobo Shi, Huimin Zhao, Huimin Zhao, Huimin Zhao   +4 more
doaj   +1 more source

Investors refuse to back genetic engineering [PDF]

, 1979

openalex   +1 more source

Defining the Agricultural Biotechnology Policy of the Philippines [PDF]

Agricultural biotechnology offers a whole new range of possibilities to solving the problems that impinge on the productivity of the agriculture sector and its ability to feed the growing human population.
Halos, Saturnina C.
core  

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Genetic Insights Into Type 2 Diabetes Mellitus Susceptibility: A Case-Control Study of the ADIPOQ rs1501299 Polymorphism in the Population of Noakhali Region of Bangladesh

Genetics Research
Type 2 diabetes mellitus (T2DM) is a global health concern, particularly prevalent in low to middle-income countries like Bangladesh. This case-control study aims to explore the correlation between the ADIPOQ rs1501299 polymorphism and susceptibility to ...
Md. Anamul Haque, Md. Sad Salabi Sawrav, Shipan Das Gupta, Shuvo Chandra Das, Dhirendra Nath Barman, Mohammed Mafizul Islam, Md. Murad Hossain   +6 more
doaj   +1 more source

Feature engineering through two-level genetic algorithm

Machine Learning with Applications
Deep learning models are widely used for their high predictive performance, but often lack interpretability. Traditional machine learning methods, such as logistic regression and ensemble models, offer greater interpretability but typically have lower ...
Aditi Gulati, Armin Felahatpisheh, Camilo E. Valderrama   +2 more
doaj   +1 more source