Results 111 to 120 of about 5,820,249 (380)

Artificial and Natural Genetic Information Processing [PDF]

, 2017
Conventional methods of genetic engineering and more recent genome editing techniques focus on identifying genetic target sequences for manipulation.
Witzany, Guenther
core  

Engineering stochasticity in gene expression [PDF]

, 2008
Stochastic fluctuations (noise) in gene expression can cause members of otherwise genetically identical populations to display drastically different phenotypes. An understanding of the sources of noise and the strategies cells employ to function reliably
Bayer, Travis S., Ellington, Andrew D., Levy, Matthew, Simpson, Zachary B., Tabor, Jeffrey J.   +4 more
core   +1 more source

Genetic Engineering of Bacteriophages Against Infectious Diseases

Frontiers in Microbiology, 2019
Bacteriophages (phages) are the most abundant and widely distributed organisms on Earth, constituting a virtually unlimited resource to explore the development of biomedical therapies.
Yibao Chen, Himanshu Batra, Junhua Dong, Cen Chen, V. Rao, Pan Tao   +5 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Genetic Engineering in Bacteria, Fungi, and Oomycetes, Taking Advantage of CRISPR

DNA
Genetic engineering has revolutionized our ability to modify microorganisms for various applications in agriculture, medicine, and industry. This review examines recent advances in genetic engineering techniques for bacteria, fungi, and oomycetes, with a
Piao Yang, Abraham Condrich, Ling Lu, Sean Scranton, Camina Hebner, Mohsen Sheykhhasan, Muhammad Azam Ali   +6 more
doaj   +1 more source

Application of the endogenous CRISPR-Cas type I-D system for genetic engineering in the thermoacidophilic archaeon Sulfolobus acidocaldarius

, 2023
Jan Bost, Alejandra Recalde, Bianca Waßmer, Alexander Wagner, Bettina Siebers, Sonja‐Verena Albers   +5 more
openalex   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Complexation of DNA with Cationic Surfactant

, 1999
Transfection of an anionic polynucleotide through a negatively charged membrane is an important problem in genetic engineering. The direct association of cationic surfactant to DNA decreases the effective negative charge of the nucleic acid, allowing the
Akhtar, Alexander, Anderson, Bennett, Blaese, Crooke, Debye, Farhood, Felgner, Felgner, Felgner, Fisher, Friedmann, Gao, Gorelov, Hodgson, Hope, Israelachvili, Juliano, Kuhn, Langer, Lasic, Levin, Manning, Manning, Marcia C. Barbosa, Paulo S. Kuhn, Shirahama, Sullivan, Verma, Yan Levin   +30 more
core   +2 more sources

Nanotechnology to advance CRISPR–Cas genetic engineering of plants

Nature Nanotechnology, 2021
Gozde S. Demirer, Tallyta N. Silva, Christopher T. Jackson, Jason B. Thomas, David W. Ehrhardt, S. Rhee, J. Mortimer, M. Landry   +7 more
semanticscholar   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source