Results 161 to 170 of about 723,030 (329)

CIGB-247 vaccine breaks immunological tolerance to the vascular endothelial growth factor in mice, rats, rabbits and non-human primates, without disturbing physiologic angiogenic processes

Biotecnología Aplicada
CIGB-247 is a novel cancer therapeutic vaccine that uses a mutated form of human vascular endothelial growth factor (VEGF) as antigen in combination with the oil-free adjuvant VSSP (very small sized proteoliposomes of Neisseria meningitidis outer ...
Yanelys Morera, Mónica Bequet, Marta Ayala, Jorge V Gavilondo, Jorge Castro, Pedro Puente, Julio Ancízar, José Suarez, Javier Sanchez, Karelia Cosme, Dania Bacardí, Boris E Acevedo   +11 more
doaj  

Agricultural policy implications of biotechnology [PDF]

Advances in genetic engineering involve more than scientific breakthroughs. Potential economic effects - some possibly undesirable - also need to be considered.biotechnology; agricultural commodities; agricultural ...
Carter, Harold O., Logan, Samuel H., Lohr, Luanne   +2 more
core   +1 more source

NanoCMSer: a consensus molecular subtype stratification tool for fresh‐frozen and paraffin‐embedded colorectal cancer samples

Molecular Oncology, EarlyView.
Consensus molecular subtypes (CMS1‐4) have been identified to study colorectal cancer heterogeneity and serve as potential biomarkers. In this study, we developed and evaluated NanoCMSer, a NanoString‐based classifier using 55 genes, optimized for FF and FFPE to facilitate the clinical evaluation of CMS subtyping.
Arezo Torang, Simone van de Weerd, Veerle Lammers, Sander van Hooff, Inge van den Berg, Saskia van den Bergh, Miriam Koopman, Jan N. IJzermans, Jeanine M. L. Roodhart, Jan Koster, Jan Paul Medema   +10 more
wiley   +1 more source

Editorial: Genetic engineering in farm animals

Frontiers in Genetics, 2023
Bjoern Petersen
doaj   +1 more source

Coupling Optimization using Design Structure Matrices and Genetic Algorithm [PDF]

arXiv
This article seeks to contribute to a nuanced understanding of the integration of Design Structure Matrix (DSM) and genetic algorithms in the context of Complex Systems modelling described within Model-Based System Engineering approach. By examining coupling minimization as a critical aspect of advanced systems engineering practices, we aim to provide ...
arxiv  

Intramammary Infusion Technique for Genetic Engineering of the Mammary Gland

, 1984
Stuart Patton, Ulrich Welsch, Sarjant Singh   +2 more
openalex   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Tilapia somatotropin polypeptides: potent enhancers of fish growth and innate immunity

Biotecnología Aplicada
Growth hormone (GH) is a single chain polypeptide of approximately 22 kDa, produced by the pituitary gland and with pleiotropic functions among vertebrates. It mainly regulates body growth, being also involved in reproduction, immunity and osmoregulation
Jannel Acosta, Estrada, Yamila Carpio, Odalys Ruiz, Reynold Morales, Eduardo Martínez, Jorge Valdés, Carlos Borroto, Vladimir Besada, Aniel Sánchez, Fidel Herrera   +10 more
doaj  

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

Comparative immunogenicity and protective capacity of two Dengue-4 vaccine candidates based on P64k-envelope domain III

Biotecnología Aplicada
In this work we compared, in the same immunization schedule in mice, two vaccine candidates against Dengue-4 based on the envelope protein domain III and the carrier P64k.
Laura Lazo, Lázaro Gil, Aída Zulueta, Iris Valdés, Yordanka Soria, Yaremis Romero, Gerardo Guillén, Lisset Hermida   +7 more
doaj