Results 191 to 200 of about 1,119,255 (298)

Genetic engineering [PDF]

, 2011
German, E.V., Proniaieva, Viktoriia Eduardivna, Проняева, Виктория Эдуардовна, Проняєва, Вікторія Едуардівна   +3 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

From Genetic Engineering to Preclinical Safety: A Study on Recombinant Human Interferons. [PDF]

Int J Mol Sci
Ramos TI, Villacis-Aguirre CA, Lamazares E, Manrique-Suárez V, Sandoval F, Culqui-Tapia CN, Martin-Solano S, Mansilla R, Cabezas I, Sánchez O, Donoso-Erch S, Parra NC, Contreras MA, Santiago-Vispo N.   +13 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

A comprehensive review of genomic-scale genetic engineering as a strategy to improve bacterial productivity. [PDF]

Microbiology (Reading)
Pantoja-Alonso MA, Camas-Reyes JA, Cano-Segura R, Cárdenas-Aquino MDR, Martínez-Antonio A.   +4 more
europepmc   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Genetic engineering to improve resistance against heavy metal stress in <i>Synechocystis</i> sp. PCC 6803. [PDF]

Appl Environ Microbiol
Yang Y, Zheng C, Gao L, Jiang X, Xu J, Zhang W, Peng Y, Han J, Sun M, Ma W, Shi W, Shen X.   +11 more
europepmc   +1 more source

Genetic Circuitry and the Future of Engineering [PDF]

, 2019
Nolan, Nick
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Genetic engineering and allogeneic optimization of Vδ1 γδ CAR-T cells (ADI-270) for cancer immunotherapy. [PDF]

J Immunother Cancer
Liu W, Moriarity BS, Webber BR.
europepmc   +1 more source