Results 71 to 80 of about 1,062,704 (335)
Robust optimization of cardiovascular stents: A comparison of methods [PDF]
, 2004 This is the post-print version of the Article. The official published version can be accssed from the links below. Copyright @ 2004 Taylor & FrancisModern engineering design contains both creative and analytic components.
Atherton, MA, Bates, RA
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Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Efforts and Challenges in Engineering the Genetic Code
Life, 2017 This year marks the 48th anniversary of Francis Crick’s seminal work on the origin of the genetic code, in which he first proposed the “frozen accident” hypothesis to describe evolutionary selection against changes to the genetic code that cause ...
Xiao Lin +2 more
doaj +1 more source
DIANA, a program for Feynman Diagram Evaluation [PDF]
, 1999 A C-program DIANA (DIagram ANAlyser) for the automatic Feynman diagram evaluation is presented.Comment: LaTeX, 5 pages, no figures; talk given at 6th International Workshop on Software Engineering, Artificial Intelligence, Neural Nets, Genetic ...
Fleischer, J., Tentyukov, M.
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Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin-Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia [PDF]
, 2018 Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a familial arrhythmogenic syndrome characterized by sudden death. There are several genetic forms of CPVT associated with mutations in genes encoding the cardiac ryanodine receptor (RyR2 ...
Belevych, Andriy E +12 more
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FEBS Letters, EarlyView.Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield +3 more
wiley +1 more source
Re-engineering of RuBisCO for the purpose of producing algal biofuels may be a lost cause
Advancements in Life Sciences, 2016 Proponents of algal biofuels hope that photosynthesis could be improved, which would make them economically feasible. One of the means to do that would be by engineering and making the slow enzyme RuBisCO more efficient.
Svetoslav Dimitrov Alexandrov
doaj
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
Genetic engineering possibilities for CELSS: A bibliography and summary of techniques [PDF]
A bibliography of the most useful techniques employed in genetic engineering of higher plants, bacteria associated with plants, and plant cell cultures is provided. A resume of state-of-the-art genetic engineering of plants and bacteria is presented. The
Johnson, E. J.
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Inverse design of cooperative electromagnetic interactions
, 2013 The cooperative electromagnetic interactions between discrete resonators have been widely used to modify the optical properties of metamaterials. Here we propose a general evolutionary approach for engineering these interactions in arbitrary networks of ...
Ben-Abdallah, Philippe +3 more
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