Results 121 to 130 of about 581,429 (287)

The ricebean genome provides insight into Vigna genome evolution and facilitates genetic enhancement. [PDF]

Plant Biotechnol J, 2023
Francis A, Singh NP, Singh M, Sharma P, Gayacharan, Kumar D, Basu U, Bajaj D, Varshney N, Joshi DC, Semwal DP, Tyagi V, Wankhede D, Bharadwaj R, Singh AK, Parida SK, Chattopadhyay D.   +16 more
europepmc   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Genetic enhancement of climate-resilient traits in small millets: A review. [PDF]

Heliyon, 2023
Choudhary P, Shukla P, Muthamilarasan M.
europepmc   +1 more source

Human T-lymphotropic virus type 1 peptides in chimeric and multivalent constructs with promiscuous T-cell epitopes enhance immunogenicity and overcome genetic restriction [PDF]

, 1995
Michael D. Lairmore, A. M. DiGeorge, S. F. Conrad, Alex V. Trevino, R. B. Lal, Pravin T. P. Kaumaya   +5 more
openalex   +1 more source

The \u3cem\u3emir-51\u3c/em\u3e Family of MicroRNAs Functions in Diverse Regulatory Pathways in \u3cem\u3eCaenorhbditis elegans\u3c/em\u3e [PDF]

, 2012
The mir-51 family of microRNAs (miRNAs) in C. elegans are part of the deeply conserved miR-99/100 family. While loss of all six family members (mir-51-56) in C. elegans results in embryonic lethality, loss of individual mir-51 family members results in a
Abbott, Allison L., Brenner, John L., Kemp, Benedict J   +2 more
core   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Silage maize as a potent candidate for sustainable animal husbandry development-perspectives and strategies for genetic enhancement. [PDF]

Front Genet, 2023
Karnatam KS, Mythri B, Un Nisa W, Sharma H, Meena TK, Rana P, Vikal Y, Gowda M, Dhillon BS, Sandhu S.   +9 more
europepmc   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Rice biofortification: breeding and genomic approaches for genetic enhancement of grain zinc and iron contents. [PDF]

Front Plant Sci, 2023
Senguttuvel P, G P, C J, D SR, Cn N, V J, P B, R G, J AK, Sv SP, Lv SR, As H, K S, D S, Rm S, Govindaraj M.   +15 more
europepmc   +1 more source

Etiology of fasting hyperbilirubinemia: Genetic factors versus enhanced enterohepatic cycling of bilirubin [PDF]

, 1999
Libor Vı́tek
openalex   +1 more source