Results 161 to 170 of about 599,012 (334)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Genetic Enhancements and Relational Autonomy: Christian Ethics and the Child’s Autonomy in Vulnerability [PDF]

, 2018
Alexander Maßmann
openalex   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Investigating the distributional response of the rare and endangered plant Fritillaria przewalskii to climate change based on optimized MaxEnt model

Scientific Reports
Climate change will lead to changes in the suitable ranges of certain species and accelerate the decline of global biodiversity, with alpine plants are particularly sensitive to these changes. Fritillaria przewalskii, a primary source for the traditional
Pengbin Dong, Liyang Wang, Lingjuan Wang, Maolin Lei, Daiyu Qiu, Gang Bai, Feng-Xia Guo, Yuan Chen   +7 more
doaj   +1 more source

Genetic enhancement of essential amino acids for nutritional enrichment of maize protein quality through marker assisted selection. [PDF]

Physiol Mol Biol Plants, 2020
Kaur R, Kaur G, Vikal Y, Gill GK, Sharma S, Singh J, Dhariwal GK, Gulati A, Kaur A, Kumar A, Chawla JS.   +10 more
europepmc   +1 more source

Is Genetic Enhancement a Gift to Future Generations?

AMA Journal of Ethics, 2000
Although parents may someday have the ability to enhance the complex physical and mental traits of their offspring, such genetic enhancements raise a number of difficult ethical questions. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
openaire   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Genomic Analysis of Selected Maize Landraces from Sahel and Coastal West Africa Reveals Their Variability and Potential for Genetic Enhancement. [PDF]

Genes (Basel), 2020
Nelimor C, Badu-Apraku B, Garcia-Oliveira AL, Tetteh A, Paterne A, N'guetta AS, Gedil M.   +6 more
europepmc   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source