Results 71 to 80 of about 599,012 (334)

Equality of Opportunity versus Sufficiency of Capabilities in Healthcare [PDF]

, 2016
The paper compares three accounts of distributive justice in health (and more specifically healthcare). I discuss two egalitarian accounts—Daniels's fair equality of opportunity for health and Segall's luck-egalitarian equity in health—and contrast them ...
Tiktin, Efrat Ram
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Comparative proteomic analysis provides insight into a complex regulatory network of taproot formation in radish (Raphanus sativus L.)

Horticulture Research, 2018
Root vegetables: tapping into root thickening for improved yields An investigation into the proteins and genes responsible for taproot thickening in radish could help improve yields of root vegetables.
Yang Xie, Liang Xu, Yan Wang, Lianxue Fan, Yinglong Chen, Mingjia Tang, Xiaobo Luo, Liwang Liu   +7 more
doaj   +1 more source

Genetic engineering to enhance mercury phytoremediation [PDF]

Current Opinion in Biotechnology, 2009
Most phytoremediation studies utilize merA or merB genes to modify plants via the nuclear or chloroplast genome, expressing organomercurial lyase and/or mercuric ion reductase in the cytoplasm, endoplasmic reticulum or within plastids. Several plant species including Arabidopsis, tobacco, poplar, rice, Eastern cottonwood, peanut, salt marsh grass and ...
Ruiz, Oscar N., Daniell, Henry
openaire   +4 more sources

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Repugnance as Performance Error: The Role of Disgust in Bioethical Intuitions [PDF]

, 2016
An influential argument in bioethics involves appeal to disgust, calling on us to take it seriously as a moral guide (e.g. Kass, Miller, Kahan). Some argue, for example, that genetic enhancement, especially via human reproductive cloning, is repellant or
May, Joshua
core  

The use of genes for performance enhancement: doping or therapy? [PDF]

, 2011
Recent biotechnological advances have permitted the manipulation of genetic sequences to treat several diseases in a process called gene therapy. However, the advance of gene therapy has opened the door to the possibility of using genetic manipulation ...
Collares, T. F., Collares, T. V., Oliveira, R. S., Seixas, F. K., Smith, Kevin R.   +4 more
core   +5 more sources

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Moral enhancement: do means matter morally? [PDF]

, 2015
One of the reasons why moral enhancement may be controversial, is because the advantages of moral enhancement may fall upon society rather than on those who are enhanced.
AFG Leentjes, CL Conti, D DeGrazia, D DeGrazia, D Ridder De, E Gisquet, E Pappadopulos, F Focquaert, F Jotterand, Farah Focquaert, FD Arani, H Gevensleben, H Greely, HG Bradshaw, I Persson, I Persson, J Bronstein, J Decety, J Harris, J Harris, J Harris, J Harris, J Pujol, J Riis, J Savulescu, JC Bublitz, JM Jansen, K Raus, K Raus, L Klaming, L Pascual, L Young, LS Bërgstrom, M Schechtman, M Schechtman, M Schermer, M Schüpbach, M Synofzik, M Walker, Maartje Schermer, MJ Crockett, MS McKenna, N Agar, NA Vincent, PP Deyn De, S Chan, S Haan De, T Douglas, T Douglas, TM Sokhadze   +49 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source