Results 81 to 90 of about 240,164 (313)

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Physiological Response of Dendrobium Udomsri Beauty under Low-temperature Treatment

HortScience
Denphal-type Dendrobium is the famous cut and potted flower in the world, and most cultivated in tropical and subtropical regions. However, it often suffers from cold in winter in subtropical regions.
Xiaoyun Yu, Shunjin Mo, Zhiqun Zhang, Shunjiao Lu, Yi Liao, Junhai Niu, Junmei Yin, Shuangshuang Yi   +7 more
doaj   +1 more source

Genetic control of enhanced mutability of mitochondrial DNA and gamma-ray sensitivity in Saccharomyces cerevisiae. [PDF]

, 1979
F. Foury, A. Goffeau
openalex   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

A MADS-box gene is involved in soybean resistance to multiple Soybean mosaic virus strains

Crop Journal, 2022
Soybean mosaic virus (SMV) is a member of the genus Potyvirus that extensively impairs global soybean production. The full-length coding sequence of the MADS-box transcription factor GmCAL was cloned from the SMV-resistant soybean cultivar Kefeng 1.
Qiuyan Ren, Hua Jiang, Wenyang Xiang, Yang Nie, Song Xue, Haijian Zhi, Kai Li, Junyi Gai   +7 more
doaj  

Genetic enhancement of okra [Abelmoschus esculentus (L.) Moench] germplasm through wide hybridization. [PDF]

Front Plant Sci, 2023
Suma A, Joseph John K, Bhat KV, Latha M, Lakshmi CJ, Pitchaimuthu M, Nissar VAM, Thirumalaisamy PP, Pandey CD, Pandey S, Kumar A, Gautam RK, Singh GP.   +12 more
europepmc   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Editorial: Trait mining and genetic enhancement of millets and potential crops: modern prospects for ancient grains. [PDF]

Front Plant Sci, 2023
Joshi DC, Sood S, Kudapa H, Zhou M, Santra D.   +4 more
europepmc   +1 more source

Adaptation of model genetically engineered microorganisms to lake water: growth rate enhancements and plasmid loss [PDF]

, 1992
Patricia A. Sobecky, Mark A. Schell, Mary Ann Moran, Robert E. Hodson   +3 more
openalex   +1 more source

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

FEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter, James Larson, Monika Tokmina‐Lukaszewska, Jin Xiong, Jared Green, Yisong Guo, William E. Broderick, Brian Bothner, Joan B. Broderick   +8 more
wiley   +1 more source