Results 171 to 180 of about 893,241 (269)

Genetic Evaluation of Barrel Racing Performance in Quarter Horses. [PDF]

J Anim Breed Genet
Santana ML, Franco TGB, Bignardi AB.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Comprehensive farm-level analysis of environmental and management descriptors for developing an efficient genetic evaluation of pasture-raised beef cattle. [PDF]

Transl Anim Sci
Santana TEZ, Veroneze R, Menezes GRO, Rosa GJM.   +3 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Genetic Evaluation of Early Growth Traits in Yunnan Semi-Fine Wool Sheep. [PDF]

Animals (Basel)
Wang Y, Yang H, Zhao X, Ni X, Zhao Y, You Z, Lu Q, Tang S, Quan G, Fu X.   +9 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Incomplete Family History and Meeting Algorithmic Criteria for Genetic Evaluation of Hereditary Cancer.

JAMA Netw Open
Harris A, Bather JR, Bradshaw RL, Kawamoto K, Del Fiol G, Kohlmann WK, Chavez-Yenter D, Monahan R, Chambers RL, Sigireddi M, Goodman MS, Kaphingst KA.   +11 more
europepmc   +1 more source

Conservation genetic evaluation of Juniperus communis sensu lato in Slovakia. [PDF]

Sci Rep
Klobučník M, Kormuťák A, Jurčík J, Galgóci M.   +3 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Genetic Evaluation of Patients with Clinically Suspected Hereditary Spastic Paraplegia with Seven Novel Variants. [PDF]

Ann Indian Acad Neurol
Özdemir TR, Gençpınar P, Sarıteke R, Dagdas SM, Haspolat S, Tiftikcioglu BI, Dündar NO, Özyılmaz B.   +7 more
europepmc   +1 more source