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Evaluating Neanderthal Genetics and Phylogeny
Journal of Molecular Evolution, 2006The retrieval of Neanderthal (Homo neanderthalsensis) mitochondrial DNA is thought to be among the most significant ancient DNA contributions to date, allowing conflicting hypotheses on modern human (Homo sapiens) evolution to be tested directly. Recently, however, both the authenticity of the Neanderthal sequences and their phylogenetic position ...
Hebsgaard, Martin B +4 more
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Genetic Evaluation of Familial Cardiomyopathy
Journal of Cardiovascular Translational Research, 2008Hereditary forms of hypertrophic, dilated, restrictive, and right ventricular cardiomyopathies are frequently seen. Patterns of inheritance include autosomal dominant, autosomal recessive, X-linked, and matrilinear. Recognition of the mode of inheritance facilitates proper clinical screening of family members in subsequent generations.
Daniel P, Judge, Nicole M, Johnson
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Connectedness in Genetic Evaluation
1990The problem of connectedness in genetic evaluation is part of the more general one of “adjusting” for nuisance parameters (e.g., herd x year x season) and of estimating genetic population means (group effects). After a review of approaches to the study of connectedness, its impact is discussed in relation to the type of model used (purely fixed or ...
Foulley, Jean Louis, J. L. +3 more
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Veterinary Clinics of North America: Food Animal Practice
Genetic evaluations in beef cattle have evolved over the past 50 years relative to the hardware or software used, the statistical methodology underpinning them, and the traits evaluated. However, the underlying premise has remained the same; to generate predictions of genetic merit such that selection decisions can be made that materialize as ...
Matthew L, Spangler, Donagh P, Berry
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Genetic evaluations in beef cattle have evolved over the past 50 years relative to the hardware or software used, the statistical methodology underpinning them, and the traits evaluated. However, the underlying premise has remained the same; to generate predictions of genetic merit such that selection decisions can be made that materialize as ...
Matthew L, Spangler, Donagh P, Berry
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Genetic toxicity evaluation of octamethylcyclotetrasiloxane
Environmental and Molecular Mutagenesis, 2000Octamethylcyclotetrasiloxane (OMCTS; CAS No. 556-67-2) was evaluated in a genetic toxicity battery. In preincubation tests with Salmonella typhimurium strains TA98, TA100, TA1535, TA1537, and TA1538, no mutagenicity was detected (maximum dose = 5 mg/plate) with or without S9 in two independent trials.
J S, Vergnes +4 more
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Genetic evaluation and counseling for epilepsy
Nature Reviews Neurology, 2010The contribution of genetics to both rare and common epilepsies is rapidly being elucidated, and neurologists are routinely considering genetic testing in the work-up of several epilepsy syndromes of both known and unknown cause. Simultaneously, advances in molecular technology foreshadow additional discoveries in epilepsy etiology, implying a greater ...
Pal, Deb K. +2 more
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Genetic evaluation of the floppy infant
Seminars in Fetal and Neonatal Medicine, 2011Hypotonia in infants in the first year of life is a common diagnostic and management challenge for pediatricians and neonatologists. Several published clinical studies have shown that a substantial proportion of cases are accounted for by genetic disorders.
A N, Prasad, C, Prasad
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Test and evaluation by genetic algorithms
IEEE Expert, 1993A machine learning technique for automating the traditional controller tests process that evaluates autonomous-vehicle software controllers is discussed. In the proposed technique, a controller is subjected to an adaptively chosen set of fault scenarios in a vehicle simulator, and then a genetic algorithm is used to search for fault combinations that ...
Alan C. Schultz +2 more
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Evaluation of genetic heterogeneity in neuroblastoma
Surgery, 2002The prognosis in neuroblastoma, which is the most common solid tumor in children, tends to vary greatly, and many studies have demonstrated both clinical and biological factors to be closely correlated with the outcome. In order to select the optimal treatment according to the degree of malignancy of neuroblastoma, it is essential to accurately and ...
Tatsuro, Tajiri +3 more
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Parents' evaluations of genetic counselling
Patient Counselling and Health Education, 1980Genetic counseling represents a new and important health service, but little is known about how the clients of genetic clinics actually experience and view the genetic counseling process. This paper reports on the evaluations made by clients of a genetics clinic and their recommendations for ways to improve and expand this service.
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