Results 271 to 280 of about 17,950,884 (399)

The use of random amplified polymorphic DNA to evaluate the genetic variability of Ponkan mandarin (Citrus reticulata Blanco) accessions [PDF]

, 2000
Helvécio Della Coletta-Filho, Marcos Antônio Machado, M. Luiza P.N. Targon, Jorgino Pompeu   +3 more
openalex   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

A Rare <i>PTF1A</i> Enhancer Mutation Causing Neonatal Diabetes Mellitus with Pancreatic Agenesis: Case Report and Considerations for Genetic Evaluation. [PDF]

Int J Endocrinol Metab
Paksaz M, Saneifard H, Mirdehghan A, Mosallanejad A, Shakiba M, Saberi M.   +5 more
europepmc   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Phylogenetic analysis and genetic evaluation of the Echinococcus granulosus antigen B subunit 2 gene isolated from sheep in Al-Diwaniyah, Iraq. [PDF]

Open Vet J
Hamad WA, Jawad TI, Atiya WH.
europepmc   +1 more source

Evaluation of Visual Features of Textile Designs Using Genetic Algorithm

, 1998
Ken‐ichi Ohta, Mitsuya Saeki, Chikako Yamada, Toyonori Nishimatsu   +3 more
openalex   +2 more sources

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Unusual familial cystic kidney disease: combining fine radiologic and genetic evaluation to solve the case. [PDF]

BMC Nephrol
Bodard S, Nabbout R, Hélénon O, Knebelmann B.   +3 more
europepmc   +1 more source

HIV-1 Diversity in Brazil: Genetic, Biologic, and Immunologic Characterization of HIV-1 Strains in Three Potential HIV Vaccine Evaluation Sites

, 2000
Vera Bongertz, Dumith Chequer Bou‐Habib, Luís Fernando de Macedo Brígido, Marcos Montani Caseiro, P. J. N. Chequer, José Carlos Couto-Fernandez, Paulo César Peregrino Ferreira, Bernardo Galvão‐Castro, Donatella Greco, Monick Lindenmeyer Guimarães, M. I. Linhares de Carvalho, Mariza Gonçalves Morgado, Carmem Aparecida de Freitas Oliveira, Saladin Osmanov, Carlos Alberto do Nascimento Ramos, Marika Rossini, Éster Cerdeira Sabino, Amílcar Tanuri, Minoru Ueda   +18 more
openalex   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source