Results 191 to 200 of about 1,488,947 (292)

Cross-species characterization of feline parvovirus and Feline-Origin canine parvovirus Southern China (2023-2024): insights into epidemiology, genetic evolution and recombination. [PDF]

BMC Vet Res
Fang N, Li M, Zhang A, Wen L, Li H, Ye X, Zhang F, Chen R.   +7 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Genetic evolution and alterations in pathogenicity of highly pathogenic porcine reproductive and respiratory syndrome virus. [PDF]

Virulence
Li C, Xu H, Li J, Gong B, Guo Z, Xiang L, Zhang S, Sun Q, Zhao J, Zhang M, Leng C, Zhao K, Wu J, Wang Q, Peng J, Zhou G, Liu H, An T, Cai X, Tian ZJ, Tang YD, Zhang H.   +21 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Genetic Evolution Between HIV-1 Groups M and O: HIV-1/MO Recombinant Forms. [PDF]

J Med Virol
Moisan A, Tombette F, Plantier JC.
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Correction to "Genetic evolution and relapse-associated mutations in adult T-cell acute lymphoblastic leukemia patients treated in PETHEMA trials". [PDF]

Hemasphere
europepmc   +1 more source

Genetic evolution and molecular characteristics of avian influenza viruses in Jining from 2018 to 2023. [PDF]

Front Microbiol
Zhao M, Dou H, Jiang Y, Jia Y, Yue Y, Li L, Huang S, Si M, Wang J, Jiao B, Wang X.   +10 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Genetic evolution of swine vesicular disease viruses circulating in Italy from 1992 to the eradication in 2015 and emergence of a recent recombinant strain. [PDF]

Virus Evol
Bregoli A, Benedetti D, Calzolari M, Benevenia R, Di Nardo A, Castelli A, Corsa M, Grazioli S, Chiapponi C, Brocchi E, Pezzoni G.   +10 more
europepmc   +1 more source