Results 211 to 220 of about 1,500,618 (293)

The genetics of evolution and the evolution of genetics¹ [PDF]

Journal of Evolutionary Biology, 1991
openaire   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, Volume 20, Issue 6, Page 1388-1391, June 2026.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Genetic Evolution Between HIV-1 Groups M and O: HIV-1/MO Recombinant Forms. [PDF]

J Med Virol
Moisan A, Tombette F, Plantier JC.
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Correction to "Genetic evolution and relapse-associated mutations in adult T-cell acute lymphoblastic leukemia patients treated in PETHEMA trials". [PDF]

Hemasphere
europepmc   +1 more source

Genetic evolution and molecular characteristics of avian influenza viruses in Jining from 2018 to 2023. [PDF]

Front Microbiol
Zhao M, Dou H, Jiang Y, Jia Y, Yue Y, Li L, Huang S, Si M, Wang J, Jiao B, Wang X.   +10 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Genetic evolution analysis of PRRSV ORF5 gene in five provinces of Northern China in 2024. [PDF]

BMC Vet Res
Jian Y, Lu C, Shi Y, Kong X, Song J, Wang J.   +5 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Molecular Epidemic Characteristics and Genetic Evolution of Porcine Circovirus Type 2 in Henan, China. [PDF]

Vet Sci
Peng Z, Lv H, Zhang H, Zhao L, Li H, He Y, Zhao K, Qiao H, Song Y, Bian C.   +9 more
europepmc   +1 more source