Results 51 to 60 of about 56,733 (259)

Predicting 28-day compressive strength of fibre-reinforced self-compacting concrete (FR-SCC) using MEP and GEP

open access: yesScientific Reports
The utilization of Self-compacting Concrete (SCC) has escalated worldwide due to its superior properties in comparison to normal concrete such as compaction without vibration, increased flowability and segregation resistance.
Waleed Bin Inqiad   +3 more
doaj   +1 more source

Intelligent assessment of damage and prediction of seismic damage spectrum under the effect of Near-Fault earthquakes in Iran [PDF]

open access: yesمهندسی عمران شریف
Predicting seismic damage spectra and capturing both structural and earthquake features are crucial for the design of new buildings and also for the resilience evaluation of existing ones.
R. Fazli, M. Shamekhi Amiri, H. Pahlavan
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Traveling-Salesman-Problem Algorithm Based on Simulated Annealing and Gene-Expression Programming

open access: yesInformation, 2018
The traveling-salesman problem can be regarded as an NP-hard problem. To better solve the best solution, many heuristic algorithms, such as simulated annealing, ant-colony optimization, tabu search, and genetic algorithm, were used.
Ai-Hua Zhou   +6 more
doaj   +1 more source

Measuring Facial Emotional Expressions Using Genetic Programming [PDF]

open access: yes, 2002
Genetic Programming techniques can be used to produce regression equations that quantify emotional expressions on a facial model. The formulae give emotional scores based on the position of 25 automatically generated ilandmarksi on the face. The method shown here is an integrated part of a system that maps multidimensional data sets to naturalistic ...
A. Loizides, M. Slater, W. B. Langdon
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Automatic Complex Function Discovery based on Multi Expression Gene Programming

open access: yes工程科学与技术, 2008
:For complex function mining, traditional gene expression programming (GEP) needs large number of evolutionary generations and may plunge into local optimum.
Dai Shu-cheng, TANG Chang-jie, 朱明放
doaj  

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

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