Results 131 to 140 of about 214,671 (312)

Generation of Space Shooter Level Using Genetic Approach

Jurnal Informatika, 2019
In this article, we used genetic algorithm and geometric-based approach to generating level for 2D space shooter game. We used the defined fitness value from game designer to limit the fitness value of the genetic algorithm process.
Ahmad Hamdani, Wahyu Andhyka Kusuma
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Genetic tools for studying adaptation and the evolution of behavior

, 2014
C.R.B.B. acknowledges support from the National Science Foundation (NSF; grants IBN‐0086955 and IBN‐0120394), which funded the workshops and symposium that produced this article. A.J.M. and M.G.R.
Ritchie, M G, Moore, A J, Taylor, B J, Wolf, J B, Breden, F, Boake, C R B, Meffert, L M, Arnold, S J   +7 more
core   +1 more source

QTL mapping reveals the genetic architecture of loci affecting pre- and post-zygotic isolating barriers in Louisiana Iris

BMC Plant Biology, 2012
Background Hybridization among Louisiana Irises has been well established and the genetic architecture of reproductive isolation is known to affect the potential for and the directionality of introgression between taxa. Here we use co-dominant markers to
Ballerini Evangeline S, Brothers Amanda N, Tang Shunxue, Knapp Steven J, Bouck Amy, Taylor Sunni J, Arnold Michael L, Martin Noland H   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Environment-dependent genetic correlations between development time and body mass in a scorpionfly

, 2007
Engqvist L. Environment-dependent genetic correlations between development time and body mass in a scorpionfly. Zoology. 2007;110(5):344-353.Development time and body mass at maturation are two important fitness traits fundamental for our understanding ...
Engqvist, Leif ; https://orcid.org/
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Genetic Programming with Fitness Based on Model Checking [PDF]

, 2007
Model checking is a way of analysing programs and program-like structures to decide whether they satisfy a list of temporal logic statements describing desired behaviour. In this paper we apply this to the fitness checking stage in an evolution strategy for learning finite state machines.
openaire   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Perspective:Sign Epistasis and Genetic Constraint on Evolutionary Trajectories

, 2005
Epistasis for fitness means that the selective effect of a mutation is conditional on the genetic background in which it appears. Although epistasis is widely observed in nature, our understanding of its consequences for evolution by natural selection ...
Weinreich, Daniel M., Watson, Richard A., Chao, Lin   +2 more
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