Results 251 to 260 of about 53,278 (329)

Fast cycle of vagus nerve stimulation is associated with increased sleep‐related breathing disorder in patients with epilepsy

Epilepsia, EarlyView.
Abstract Objective This work was undertaken to study the association between vagus nerve stimulation (VNS) parameters and the apnea–hypopnea index (AHI) measured by polysomnography in patients with drug‐resistant epilepsy. Methods Patients with epilepsy who underwent polysomnography with an active VNS device between 2018 and 2023 were retrospectively ...
Jacques‐François Massa, Nada El Youssef, Romain Carron, Pauline Garcia, Agnès Trebuchon, Bernard Giusiano, Fabrice Bartolomei, Angela Marchi, Isabelle Lambert   +8 more
wiley   +1 more source

Bidirectional sleep‐seizure interactions and orexin in a mouse model of tuberous sclerosis complex‐related epilepsy

Epilepsia, EarlyView.
Abstract Objective A strong bidirectional relationship exists between epilepsy and sleep, with seizures often occurring more frequently in sleep and, in turn, sleep being disrupted by seizures. However, the mechanistic basis of seizure–sleep interactions is poorly understood.
Nicholas R. Rensing, Lirong Han, Dongjun Guo, Thomas J. Foutz, Michael Wong   +4 more
wiley   +1 more source

Evolution of the European Medicines Agency clinical guidelines for epilepsy drug development between 2010 and 2025: A comparative analysis by the ILAE Task Force on Regulatory Affairs

Epilepsia, EarlyView.
Abstract Objective The latest European Medicines Agency (EMA) guideline on the clinical investigation of medicines to treat epileptic disorders was adopted by the EMA Committee for Medicinal Products for Human Use in 2025. We compared this guideline with the previous version (2010), highlighting areas where significant revisions were introduced ...
Stéphane Auvin, Alexis Arzimanoglou, Jacqueline French, Kelly G. Knupp, Lieven Lagae, Eugen Trinka, Dennis Dlugos, Emilio Perucca   +7 more
wiley   +1 more source

Sensorimotor network hypersynchrony as an endophenotype in families with genetic generalized epilepsy: A resting-state functional magnetic resonance imaging study. [PDF]

Epilepsia, 2019
Tangwiriyasakul C, Perani S, Abela E, Carmichael DW, Richardson MP.   +4 more
europepmc   +1 more source

Real-time detection of epileptic seizures in animal models using reservoir computing [PDF]

, 2013
Boon, Paul, Buteneers, Pieter, Raedt, Robrecht, Schrauwen, Benjamin, Stroobandt, Dirk, Van Nieuwenhuyse, Bregt, Verstraeten, David, Vonck, Kristl   +7 more
core   +1 more source

KCNJ4 variants disrupt inward‐rectifier potassium channel function and cause refractory epilepsy

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a common neurological disorder with a strong genetic basis, most frequently arising from ion channel dysfunction. Although multiple inwardly rectifying potassium (Kir) channels have been implicated in epileptogenesis, the contribution of KCNJ4, which encodes the Kir2.3 channel, has not previously been established in human
Hu Pan, Deng Liu, Wuhen Xu, Yang Li, Juanli Hu, Oppermann Henry, Alexander Fuchs, Rami Abou Jamra, Zhen Liu, Mei He, Yuanlu Chen, Shengnan Wu, Xiaohuan Dong, Yiqiao Chen, Pengchao Wang, Weiyue Gu, Han Jing, Yabing Tang, Ya‐Jie Wang, Xiao Mao, Neng Xiao   +20 more
wiley   +1 more source

Persons with epilepsy and their caregivers understand the definition of ictal impairment of consciousness

Epilepsia, EarlyView.
Abstract The term consciousness has been reintroduced in the updated seizure classification. Concerns have been raised that "ictal impaired consciousness" may be misunderstood by persons with epilepsy (PWEs) and their caregivers, particularly that English‐speaking individuals might equate it with complete loss of consciousness.
Kaley J. Marcinski Nascimento, Fábio A. Nascimento, Torie Robinson, Birgit Frauscher, Eugen Trinka, Sándor Beniczky   +5 more
wiley   +1 more source

Disruption of functional gradients in genetic generalized epilepsy and its clinical relevance: evidence from high-density EEG

Zhang J, Rigoni I, Van De Ville D, Vulliémoz S, Roehri N.   +4 more
europepmc   +1 more source

Replication Data for: Preliminary identification of cognitive phenotypes in temporal lobe epilepsy and genetic generalized epilepsy using robotic assessment

Theodore Aliyianis, Gavin Winston
openalex   +1 more source

Stiripentol: Unpublished results from the first phase 2 clinical trial in Lennox–Gastaut syndrome conducted in the early 1990s

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to present the results of an exploratory phase 2 trial of stiripentol in Lennox–Gastaut syndrome (LGS). Methods This exploratory single‐blind, single‐arm, nonrandomized sequential‐period phase 2 study was conducted at four centers in France between January 1989 and August 1993.
Stéphane Auvin, Benjamin Serraz, Jérémie Lespinasse, Laurent Chancharme   +3 more
wiley   +1 more source