Results 101 to 110 of about 18,747,118 (311)

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

Acta Neuropathologica, 2012
Medulloblastoma is the most common malignant brain tumor in childhood. Molecular studies from several groups around the world demonstrated that medulloblastoma is not one disease but comprises a collection of distinct molecular subgroups.
M. Kool, A. Korshunov, M. Remke, M. Remke, David T. W. Jones, Maria Schlanstein, P. Northcott, Yoon-Jae Cho, J. Koster, A. Meeteren, D. Vuurden, S. Clifford, T. Pietsch, A. Bueren, S. Rutkowski, Martin G. McCabe, Martin G. McCabe, V. Collins, M. Bäcklund, C. Haberler, F. Bourdeaut, O. Delattre, F. Doz, D. Ellison, R. Gilbertson, S. Pomeroy, Michael D. Taylor, P. Lichter, Stefan M. Pfister, Stefan M. Pfister   +29 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A new record of Asia II 5 genetic group of Bemisia tabaci (Gennadius) in the major potato growing areas of India and its relationship with tomato leaf curl New Delhi virus infecting potato. [PDF]

3 Biotech, 2021
Naga KC, Siddappa S, Kumar R, Tiwari RK, Subhash S, Verma G, Buckseth T, Bairwa A, Sharma S, Katare S, Srivastava RM, Bansode GM, Sarkar A, Patel JK.   +13 more
europepmc   +1 more source

Genetic divergence among genetic groups of Gir crossbreds

The Indian Journal of Animal Sciences, 2019
Comparative evaluation of FG (50% HF + 50% Gir), IFG (Interse of FG), FJG (50% HF + 25% Jersey + 25% Gir), IFJG (Interse of FJG) and R (50% HF + 12.50% Jersey + 37.50% Gir) crosses of Gir was done on the basis of age at first conception (AFCon), lactation length (LL) and 300 days milk yield (300 DMY) of first, second and third lactations using ...
MAHENDRA GORAKH MOTE, UDDHAV YASHWANTRAO BHOITE, CHARUDATTA ANANTRAO NIMBALKAR, SANJAY DATTATRAYA MANDAKMALE   +3 more
openaire   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Orientação e sombreamento do confinamento na temperatura da superfície do pelame de bovinos = Effect of feedlot orientation and shading on haircoat surface temperature of cattle

Acta Scientiarum: Animal Sciences, 2008
Avaliou-se o efeito do sombreamento sobre a temperatura da superfície do pelame (TSP) de bovinos de cinco grupos genéticos, 4 ½ Limousin + ½ Nelore (L), 8 ½ Limousin + ¼ Nelore + ¼ RedAngus (LR), 4 ½ Limousin + ¼ Nelore + ¼ Simental (LS), 2 ½ Marchigiana
Ricardo Kazama, Cláudio Fabrício da Cruz Roma, Orlando Rus Barbosa, Lucia Maria Zeoula, Taciana Ducatti, Lílian Christiane Tesolin   +5 more
doaj  

Validation of differentially methylated microRNAs identified from an epigenome-wide association study; Sanger and next generation sequencing approaches

BMC Research Notes, 2018
Objectives Altered DNA methylation and microRNA profiles are associated with diabetic kidney disease. This study compared different sequencing approaches to define the genetic and epigenetic architecture of sequences surrounding microRNAs associated with
Laura J. Smyth, Alexander P. Maxwell, Katherine A. Benson, Jill Kilner, Gareth J. McKay, Amy Jayne McKnight   +5 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source