Results 201 to 210 of about 545,241 (266)

Efficient CRISPR/<i>Cas</i>9-mediated genome editing of phytoene desaturase in <i>Musa</i>-AAA: a critical step for genetic improvement of east African highland bananas. [PDF]

Front Plant Sci
Kalungi F, Mulindwa J, Mustafa AS, Namanya PB, Kubiriba J, Barekye A, Tindamanyire JM.   +6 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Development and Characterization of Synthetic Allotetraploids Between Diploid Species <i>Gossypium herbaceum</i> and <i>Gossypium nelsonii</i> for Cotton Genetic Improvement. [PDF]

Plants (Basel)
Arslanova SK, Ernazarova ZA, Ernazarova DK, Turaev OS, Safiullina AK, Toshpulatov AK, Kholova MD, Azimova LA, Rafiyeva FU, Gapparov BM, Gapparov BM, Khalikov KK, Khidirov MT, Iskandarov AA, Kodirov DM, Turaev OY, Maulyanov SA, Udall JA, Yu JZ, Kushanov FN.   +19 more
europepmc   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Introgression among subgroups is an important driving force for genetic improvement and evolution of the Asian cultivated rice <i>Oryza sativa</i> L. [PDF]

Front Plant Sci
Zhou J, Li J, Zhang Y, Yang Y, Lv Y, Pu Q, Deng X, Tao D.   +7 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Advancements and strategies of genetic improvement in cassava (<i>Manihot esculenta</i> Crantz): from conventional to genomic approaches. [PDF]

Hortic Res
Xiao L, Cheng D, Ou W, Chen X, Rabbi IY, Wang W, Li K, Yan H.   +7 more
europepmc   +1 more source

The whole-genome dissection of root system architecture provides new insights for the genetic improvement of alfalfa (Medicago sativa L.). [PDF]

Hortic Res
Jiang X, Zeng X, Xu M, Li M, Zhang F, He F, Yang T, Wang C, Gao T, Long R, Yang Q, Kang J.   +11 more
europepmc   +1 more source

Genetic improvement and genomic resources of important cyprinid species: status and future perspectives for sustainable production. [PDF]

Front Genet
Rasal KD, Kumar PV, Risha S, Asgolkar P, Harshavarthini M, Acharya A, Shinde S, Dhere S, Rasal A, Sonwane A, Brahmane M, Sundaray JK, Nagpure N.   +12 more
europepmc   +1 more source

Selective Breeding for Genetic Improvement of Nile tilapia (Oreochromis niloticus Linnaeus, 1758) in Uganda: Current Status, Challenges, and Future Perspectives. [PDF]

Animals (Basel)
Abaho I, Kwikiriza G, Atukwatse F, Izaara AA, Ekwangu J, Baguma SD, Kubiriba J, Kasozi N.   +7 more
europepmc   +1 more source