Results 181 to 190 of about 5,357,131 (305)

Selection index for genetic improvement of beef performance in Huaxi cattle of Xinjiang, China. [PDF]

BMC Genomics
Ahmad SZ, Feng Y, Zhang Q, Lu X, Zhao W, Zhang B, Zhong F, Han M, Chen Z.   +8 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Genetic improvement of a synthetic microbiota: a step further? [PDF]

Front Microbiol
Martínez-Porchas M, Medina-Félix D, Vargas-Albores F, Garibay-Valdez E, Méndez-Martínez Y, Martínez-Córdova LR, Ortiz-Estrada AM.   +6 more
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Maintenance breeding and breeding for yield potential both contribute to genetic improvement in wheat yield. [PDF]

Nat Commun
Andrade JF, Man J, Monzon JP, Rattalino Edreira JI, Yuan S, Lollato RP, de la Vega AJ, Llorens C, de Oliveira Silva A, Peng S, Cassman KG, Grassini P.   +11 more
europepmc   +1 more source

Genetic improvement [PDF]

, 2016
Horry, Jean-Pierre, De Langhe, Edmond
openaire  

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Precision Editing of Cis-Regulatory Elements Drives Crops Quantitative Traits Genetic Improvement: From Functional Dissection to Intelligent Design. [PDF]

Rice (N Y)
Li Y, Zhang X, Cui Y, Shang G, Wu Y, Ma Y, Tian T, Liu M, Sang S.   +8 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genetic improvement and bioactive potential of rice bean (<i>Vigna umbellata</i>) for climate resilience and sustainable agriculture. [PDF]

Front Plant Sci
Lutege RM, Stevenson PC, Chater CCC, Venkataramana P.   +3 more
europepmc   +1 more source