Results 161 to 170 of about 5,062,045 (260)

Genetic improvement of a synthetic microbiota: a step further? [PDF]

Front Microbiol
Martínez-Porchas M, Medina-Félix D, Vargas-Albores F, Garibay-Valdez E, Méndez-Martínez Y, Martínez-Córdova LR, Ortiz-Estrada AM.   +6 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Maintenance breeding and breeding for yield potential both contribute to genetic improvement in wheat yield. [PDF]

Nat Commun
Andrade JF, Man J, Monzon JP, Rattalino Edreira JI, Yuan S, Lollato RP, de la Vega AJ, Llorens C, de Oliveira Silva A, Peng S, Cassman KG, Grassini P.   +11 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Minutes of the Trustees Internal Improvement Fund of the State of Florida.

, 1906
Includes also Financial statement.Includes also Financial statement.Mode of access: Internet.Published under authority of Trustees.Continued by: Florida. Trustees of Internal Improvement Fund.
Florida. Trustees of Internal Improvement Fund.
core  

Genetic improvement and bioactive potential of rice bean (<i>Vigna umbellata</i>) for climate resilience and sustainable agriculture. [PDF]

Front Plant Sci
Lutege RM, Stevenson PC, Chater CCC, Venkataramana P.   +3 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Evaluation of mid-infrared milk spectroscopy as a tool for genetic improvement of nitrogen utilization in dairy cow. [PDF]

JDS Commun
Tavernier E, Frizzarin M, Berry DP.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Telomere-to-telomere genome assembly and a mutant library empower functional genomics and genetic improvement in Cucurbita moschata. [PDF]

Plant Commun
Li J, Chen Z, Li K, Tan J, Sun J, Deng XW, Park Y, He H, Deng Y, Zhang X.   +9 more
europepmc   +1 more source