Results 241 to 250 of about 7,966,330 (339)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Genetic Improvement of rice Grain size Using the CRISPR/Cas9 System. [PDF]

Rice (N Y)
Zhang T, Wang Z, Liu Q, Zhao D.
europepmc   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Optimization of recurrent rapid cycle breeding in maize for sustained long-term genetic improvement via stochastic simulations. [PDF]

G3 (Bethesda)
Pook T, Tost ML, Simianer H.
europepmc   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Integrating quantitative traits and <i>growth hormone</i> gene polymorphism in Indonesian crossbred chickens for genetic improvement and marker-assisted selection. [PDF]

Vet World
Depison D, Gushairiyanto G, Harahap RS, Muthalib RA, Azis A, Alwi Y, Edy Wibowo S.   +6 more
europepmc   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Potato: from functional genomics to genetic improvement. [PDF]

Mol Hortic
Qu L, Huang X, Su X, Zhu G, Zheng L, Lin J, Wang J, Xue H.   +7 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Advancing genetic improvement in the omics era: status and priorities for United States aquaculture. [PDF]

BMC Genomics
Andersen LK, Thompson NF, Abernathy JW, Ahmed RO, Ali A, Al-Tobasei R, Beck BH, Calla B, Delomas TA, Dunham RA, Elsik CG, Fuller SA, García JC, Gavery MR, Hollenbeck CM, Johnson KM, Kunselman E, Legacki EL, Liu S, Liu Z, Martin B, Matt JL, May SA, Older CE, Overturf K, Palti Y, Peatman EJ, Peterson BC, Phelps MP, Plough LV, Polinski MP, Proestou DA, Purcell CM, Quiniou SMA, Raymo G, Rexroad CE, Riley KL, Roberts SB, Roy LA, Salem M, Simpson K, Waldbieser GC, Wang H, Waters CD, Reading BJ, Aquaculture Genomics, Genetics and Breeding Workshop.   +46 more
europepmc   +1 more source