Results 251 to 260 of about 625,256 (313)

Rice Promoter Editing: An Efficient Genetic Improvement Strategy. [PDF]

Rice (N Y)
Wu B, Luo H, Chen Z, Amin B, Yang M, Li Z, Wu S, Salmen SH, Alharbi SA, Fang Z.   +9 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Integrating quantitative traits and <i>growth hormone</i> gene polymorphism in Indonesian crossbred chickens for genetic improvement and marker-assisted selection. [PDF]

Vet World
Depison D, Gushairiyanto G, Harahap RS, Muthalib RA, Azis A, Alwi Y, Edy Wibowo S.   +6 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The telomere-to-telomere gapless genome of grass carp provides insights for genetic improvement. [PDF]

Gigascience
Liu F, Li Y, Wang G, Zhang D, Yang X, Zhou C, Zhou R, Liu H.   +7 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Leveraging UAV spectral and thermal traits for the genetic improvement of resistance to Dothistroma needle blight in <i>Pinus radiata</i> D.Don. [PDF]

Front Plant Sci
Elleouet JS, Main R, Hartley RJL, Watt MS.   +3 more
europepmc   +1 more source

A large-scale gene regulatory network for rice endosperm starch biosynthesis and its application in genetic improvement of rice quality. [PDF]

Plant Biotechnol J
Huang K, Lu F, Chen P, Jiao G, Lin H, Zhang J, Zhao S, Cao R, Shao G, Sheng Z, Hu S, Tang S, Hu P, Wei X.   +13 more
europepmc   +1 more source

Livestock embryonic stem cells for reproductive biotechniques and genetic improvement. [PDF]

Anim Reprod
Navarro M, Laiz-Quiroga L, Blüguermann C, Mutto A.   +3 more
europepmc   +1 more source