Results 81 to 90 of about 7,541,678 (261)

Genetic diagnosis and prenatal diagnosis of patients with cystic kidney disease in Southwest China

BMC Nephrology
Background Cystic kidney disease is a heterogeneous chronic kidney disease. It is often difficult to make a definitive diagnosis based on clinical and ultrasound features alone.
Cong Zhou, Yuanyuan Xiao, Hanbing Xie, Xing Wei, Jing Wang   +4 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Rapidly Progressive Glomerulonephritis in Autosomal Dominant Polycystic Kidney Disease

, 2015
Patients with autosomal dominant polycystic kidney disease (ADPKD) can suffer from the same causes of acute kidney injury as the general population. Affected individuals may present with hematuria and proteinuria (usually less than 1g/day).

core   +1 more source

Precision Surgery and Kidney Cancer: Knowledge of Genetic Alterations Influences Surgical Management

, 2021
Renal cell carcinoma is a term that represents multiple different disease processes, each driven by different genetic alterations, with distinct histology, and biological potential which necessitates divergent management strategies. This review discusses
Patrick T. Gomella, W. Linehan, Mark W. Ball   +2 more
core   +1 more source

Greb1l is essential for pronephric tubule morphogenesis in zebrafish by maintaining cell homeostasis via MAPK signaling

Scientific Reports
Mutations in the human GREB1L (growth regulation by estrogen in breast cancer 1-like) gene are associated with congenital anomalies of the kidneys and urinary tracts (CAKUT). However, its precise function and molecular mechanisms remain poorly understood.
Jitong Li, Jieru Wei, Yaodong Zhang, Xiaotong Zhao, Ruijing Li, Ming Tian, Weili Yang, Weyland Cheng, Xinkui Zhou, Xingxue Yan, Cuihua Liu   +10 more
doaj   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

The prevalence and identification of chronic kidney disease in Switzerland [PDF]

, 2015
BACKGROUND: Chronic kidney disease (CKD) is characterized by a gradual loss of kidney function. Patients in early CKD stages are often asymptomatic or show non-specific symptoms.
Tomonaga, Yuki
core   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

To do or not to do—genetic testing for autosomal dominant polycystic kidney disease in children and adolescents

Despite increasing evidence of the clinical utility of genetic testing in adults with autosomal dominant polycystic kidney disease, its benefits in asymptomatic children, including adolescents, remain controversial. Although there may be medical benefits
Milo Rasouly, Hila, Sabatello, Maya, Ma, Becky Mingyao   +2 more
core   +1 more source