Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
LINKAGE EFFECTS ON ADDITIVE GENETIC VARIANCE AMONG HOMOZYGOUS LINES ARISING FROM THE CROSS BETWEEN TWO HOMOZYGOUS PARENTS [PDF]
, 1963 W. D. Hanson, B I Hayman
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Molecular Oncology, EarlyView.Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien +7 more
wiley +1 more source
LINKAGE OF GENETIC UNITS OF BACILLUS SUBTILIS IN DNA TRANSFORMATION [PDF]
, 1961 Eugene W. Nester, Joshua Lederberg
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The working principles of model-based GAs fall within the PAC framework: A mathematical theory of problem decomposition [PDF]
arXivThe concepts of linkage, building blocks, and problem decomposition have long existed in the genetic algorithm (GA) field and have guided the development of model-based GAs for decades. However, their definitions are usually vague, making it difficult to develop theoretical support.
arxiv
Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
Studies of adenovirus-SV40 hybrid viruses. V. Evidence for linkage between adenovirus and SV40 genetic materials. [PDF]
, 1966 Wallace P. Rowe, Wendell E. Pugh
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Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
Population genetic structure based on microsatellite markers in rubber tree (Hevea brasiliensis) germplasm collection : [P483] [PDF]
, 2014 Hevea brasiliensis is native to the Amazonian rain forest and an important source of natural rubber. All high-yielding cultivars of rubber tree in the world originated from breeding programs initially developed in Southeast Asia with a very narrow ...
Campos Mantello, Camila +7 more
core
Molecular Oncology, EarlyView.The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh +6 more
wiley +1 more source