Results 91 to 100 of about 547,025 (332)

Mammalian models of extended healthy lifespan [PDF]

, 2011
Over the last two centuries, there has been a significant increase in average lifespan expectancy in the developed world. One unambiguous clinical implication of getting older is the risk of experiencing age-related diseases including various cancers ...
Colin Selman, Crepaldi G., Dominic J. Withers, Duquesnoy R. J., Pelletier A. L., Silberberg R., Tomassini C., Weindruch R.   +7 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Strain prioritization and genome mining for enediyne natural products [PDF]

, 2016
The enediyne family of natural products has had a profound impact on modern chemistry, biology, and medicine, and yet only 11 enediynes have been structurally characterized to date.
Ben Shen, Christoph Rader, Dong Yang, Filip Van Nieuwerburgh, Hindra, Huiming Ge, Ivana Crnovčičć, Jeffrey D. Rudolf, Jeremy R. Lohman, Li-Xing Zhao, Qihui Teng, Tingting Huang, Xiangcheng Zhu, Xiaohui Yan, Xiuling Li, Yannick Gansemans, Yanwen Duan, Yi Jiang, Yong Huang   +18 more
core   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The review of recent advances in fish genetics and biotechnology [PDF]

, 2012
Great advances have been, and are being made in our knowledge of the genetics and molecular biology (including genomics, proteomics and structural biology).
Mgbabu , Christopher Nwokwa
core  

Synthetic biology: advancing biological frontiers by building synthetic systems [PDF]

, 2012
Advances in synthetic biology are contributing to diverse research areas, from basic biology to biomanufacturing and disease therapy.
Chen, Yvonne Y., Galloway, Kate E., Smolke, Christina D.   +2 more
core   +5 more sources

Genetic manipulation for carotenoid production in microalgae an overview

, 2022
Aswini Velmurugan, Gothandam Kodiveri Muthukaliannan   +1 more
openalex   +1 more source

Enhancement of hemostatic properties of Cyclotella cryptica frustule through genetic manipulation [PDF]

, 2023
Lulu Wang, Yan V. Sun, Ruihao Zhang, Kehou Pan, Yuhang Li, Ruibing Wang, Lin Zhang, Chengxu Zhou, Jian Li, Yun Li, Baohua Zhu, Jichang Han   +11 more
openalex   +1 more source

Impact of Genetic Manipulation

Journal of Dairy Science, 1984
Genetic progress for production in dairy cattle is 50% or less of optimum. Manipulation of the reproductive process to increase genetic gains was reviewed. Economics of manipulating the reproductive process was evaluated by equating future discounted net income to current discounted expenses and solving for the break-even cost of the technique for 1 to
openaire   +2 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source