Results 111 to 120 of about 547,025 (332)
Epigenetic Consequences of Genome Manipulations: Caveats for Human Germline Therapy and Genetically Modified Organisms [PDF]
, 2019 Walter Doerfler
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Applied and Environmental MicrobiologyThermoanaerobacterium thermosaccharolyticum is an anaerobic and thermophilic bacterium that has been genetically engineered for ethanol production at very high yields.
Layse C. de Souza +2 more
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Evolution of the discrete transform using genetic programming : a thesis presented in partial fulfilment of the requirements for the degree of Master in Computer Science at Massey University, Albany [PDF]
, 2001 Image compression is an important method in image transmission, storage and manipulation. There are many successful techniques which have been developed. Most of these methods are based on some type of rule based algorithm.
Cui, Xiangbiao
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Hybrid Evolutionary Shape Manipulation for Efficient Hull Form Design Optimisation [PDF]
, 2016 ‘Eco-friendly shipping’ and fuel efficiency are gaining much attention in the maritime industry due to increasingly stringent environmental regulations and volatile fuel prices.
Goh, Cindy, Hock, Joo, Li, Yun
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Burkholderia thailandensis: Genetic Manipulation [PDF]
Current Protocols in Microbiology, 2017 Abstract Burkholderia thailandensis is a Gram‐negative bacterium endemic to Southeast Asian and northern Australian soils. It is non‐pathogenic; therefore, it is commonly used as a model organism for the related human pathogens Burkholderia mallei and Burkholderia pseudomallei. B. thailandensis is relatively easily genetically manipulated and a variety
openaire +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
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