Results 191 to 200 of about 1,196,074 (333)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Construction of a high-density genetic map for faba bean (Vicia faba L.) and quantitative trait loci mapping of seed-related traits. [PDF]

Front Plant Sci, 2023
Zhao N, Xue D, Miao Y, Wang Y, Zhou E, Zhou Y, Yao M, Gu C, Wang K, Li B, Wei L, Wang X.   +11 more
europepmc   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

A Genetic Map of the Modern Urban Society of Amsterdam. [PDF]

Front Genet, 2021
Ferwerda B, Abdellaoui A, Nieuwdorp M, Zwinderman K.   +3 more
europepmc   +1 more source

Single nuclei chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry [PDF]

, 2023
Harikrishna Nakshatri, Poornima Bhat‐Nakshatri, Hongyu Gao, Aditi S. Khatpe, Patrick C. McGuire, Cihat Erdoğan, Duojiao Chen, Guanglong Jiang, Felicia New, Rana German, Anna Maria Storniolo, Yunlong Liu   +11 more
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

High-resolution genome and genetic map of tetraploid Allium porrum expose pericentromeric recombination. [PDF]

Plant Genome
Nieuwenhuis R, Voorrips R, Esselink D, Hesselink T, Schijlen E, Arens P, Cordewener J, van den Broeck HC, Scholten O, Peters S.   +9 more
europepmc   +1 more source

Construction of a high-density genetic map and dissection of genetic architecture of six agronomic traits in tobacco (Nicotiana tabacum L.). [PDF]

Front Plant Sci, 2023
Tong Z, Xu M, Zhang Q, Lin F, Fang D, Chen X, Zhu T, Liu Y, Xu H, Xiao B.   +9 more
europepmc   +1 more source

Integrative genetic map of repetitive DNA in the sole Solea senegalensis genome shows a Rex transposon located in a proto-sex chromosome [PDF]

, 2019
Emilio García García, Ismael Cross, Silvia Portela-Bens, María Esther Rodríguez, Aglaya García-Angulo, Belén Molina, Ángeles Cuadrado, Thomas Liehr, Laureana Rebordinos   +8 more
openalex   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source