Results 251 to 260 of about 5,464,915 (400)

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

A KRAS-variant in ovarian cancer acts as a genetic marker of cancer risk.

Cancer Research, 2010
E. Ratner, Lingeng Lu, Marta Boeke, Rachel E. Barnett, Sunitha Nallur, Lena J. Chin, Cory Pelletier, R. Blitzblau, R. Tassi, T. Paranjape, P. Hui, A. Godwin, Herbert Yu, H. Risch, T. Rutherford, P. Schwartz, A. Santin, E. Matloff, D. Zelterman, F. Slack, J. Weidhaas   +20 more
semanticscholar   +1 more source

Genetic marker: a genome mapping tool to decode genetic diversity of livestock animals. [PDF]

Front Genet
Panchariya DC, Dutta P, Ananya, Mishra A, Chawade A, Nayee N, Azam S, Gandham RK, Majumdar S, Kushwaha SK.   +9 more
europepmc   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Utilizing Short Interspersed Nuclear Element as a Genetic Marker for Pre-Harvest Sprouting in Wheat. [PDF]

Plants (Basel)
Kandpal P, Kaur K, Dhariwal R, Kaur S, Brar GK, Randhawa H, Singh J.   +6 more
europepmc   +1 more source

The first genetic characterization of Setaria marshalli (Nematoda, Spirurida) with reliable DNA barcoding based on a mitochondrial genetic marker. [PDF]

Parasite, 2022
Kitajima C, Ichijo T, Ichikawa-Seki M.
europepmc   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Marginal interaction test for detecting interactions between genetic marker sets and environment in genome-wide studies. [PDF]

G3 (Bethesda)
Shen L, Amei A, Liu B, Xu G, Liu Y, Oh EC, Zhou X, Wang Z.   +7 more
europepmc   +1 more source

Structural differences in a single gene encoding the V kappa Ser group of light chains explain the existence of two mouse light-chain genetic markers.

, 1986
R. Thomas Boyd, Marianna Goldrick, Paul Gottlieb   +2 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source