Kernel-based aggregation of marker-level genetic association tests involving copy-number variation [PDF]
, 2013 Genetic association tests involving copy-number variants (CNVs) are complicated by the fact that CNVs span multiple markers at which measurements are taken. The power of an association test at a single marker is typically low, and it is desirable to pool
Breheny, Patrick, Li, Yinglei
core +3 more sources
Structural Variants May Be a Source of Missing Heritability in sALS
Frontiers in Neuroscience, 2020 The underlying genetic and molecular mechanisms that drive amyotrophic lateral sclerosis (ALS) remain poorly understood. Structural variants within the genome can play a significant role in neurodegenerative disease risk, such as the repeat expansion in ...
Frances Theunissen +25 more
doaj +1 more source
A comparison of SNPs and microsatellites as linkage mapping markers: lessons from the zebra finch (Taeniopygia guttata) [PDF]
, 2010 Background: Genetic linkage maps are essential tools when searching for quantitative trait loci (QTL). To maximize genome coverage and provide an evenly spaced marker distribution a combination of different types of genetic marker are sometimes used.
Ball, A.D. +5 more
core +3 more sources
Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice [PDF]
, 2013 Background: Murine models are a crucial component of gut microbiome research. Unfortunately, a multitude of genetic backgrounds and experimental setups, together with inter-individual variation, complicates cross-study comparisons and a global ...
Brinkman, Brigitta +7 more
core +3 more sources
Genetic distance predicts trait differentiation at the subpopulation but not the individual level in eelgrass, Zostera marina. [PDF]
, 2018 Ecological studies often assume that genetically similar individuals will be more similar in phenotypic traits, such that genetic diversity can serve as a proxy for trait diversity.
Corre V. +6 more
core +2 more sources
Open Veterinary Science, 2021 This study aimed to investigate the genotypic distribution and population genetic parameters of the single nucleotide polymorphism (SNP) located on exon 3 at the FSHB gene in East Anatolian Red (EAR), East Anatolian Red×Holstein (EAR×H), and Zavot (Z ...
Ardicli Sena
doaj +1 more source
Genetic Dissection of Disease Resistance to the Blue Mold Pathogen, Peronospora tabacina, in Tobacco
Agronomy, 2015 Tobacco blue mold, caused by the obligately biotrophic oomycete pathogen Peronospora tabacina D.B. Adam, is a major foliar disease that results in significant losses in tobacco-growing areas. Natural resistance to P.
Xia Wu +5 more
doaj +1 more source
Revista Brasileira de Zootecnia, 2005 O procedimento de mapeamento por intervalo baseado em modelo aleatório foi aplicado para estudar sua robustez e propriedades no mapeamento de dois QTLs, em populações constituídas de famílias de meios-irmãos.
Marcos Vinicius G. Barbosa da Silva +7 more
doaj +1 more source
Genetic markers in oligodendroglial tumours [PDF]
Radiology and Oncology, 2010 Oliogodendrogliomas are brain tumours composed of the cells resembling oligodendrocytes. They represent the third most common glial tumour, comprising 2.5% of all primary brain tumours and 5-20% of all gliomas.Oligodendroglial tumours with 1p and 19q loss demonstrate a better overall prognosis due to more indolent clinical behaviour and higher ...
Bunc, Gorazd +3 more
openaire +4 more sources
Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus +6 more
wiley +1 more source