Results 121 to 130 of about 18,441,004 (311)

A population genetics model of marker-assisted selection [PDF]

, 1997
A deterministic two-loci model was developed to predict genetic response to marker-assisted selection (MAS) in one generation and in multiple generations.
Luo, Z. W., Woolliams, J. A., Luo, Z.W., Woolliams, John, Thompson, R.   +4 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Lumbar puncture increases Alzheimer’s disease biomarker levels in cerebrospinal fluid of rhesus monkeys

iScience
Summary: Cerebrospinal fluid (CSF) samples are commonly collected via lumbar puncture (LP) in both clinical and research settings for measurement of biomarkers of Alzheimer’s disease (AD). To determine the effects of LP on CSF AD biomarkers, we collected
Jianglei Xu, Hao Li, Yingzhou Hu, Shihao Wu, Liping Wu, Xiaoguang Lei, Longbao Lv, Yi Lu, Jing Wu, Juanjuan Li, Bingyin Shi, Jiali Li, Christoph W. Turck, Wenchao Wang, Xintian Hu   +14 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Molecular defense strategy of volatile organic compound-emitting plants (order Piperales) against herbivorous mammals

Communications Biology
Plants have evolved diverse strategies to defend against herbivores, including structural barriers such as trichomes and tough leaves, the production of toxic secondary metabolites, the emission of volatile organic compounds (VOCs), and the recruitment ...
Huajun Cai, Deyuan Su, Anna Luo, Yalan Han, Hao Zhang, Peter Muiruri Kamau, Haiying Wu, Ren Lai, Lei Luo   +8 more
doaj   +1 more source

Novel microbially transformed bile acids: Biosynthesis, structure, and function

Pharmacological Research
The roles of gut microbiota and microbially modified bile acids in human health have become widely recognized. In the last five years, various microbially modified bile acids (e.g., proteinogenic amino-conjugated bile acids, polyamine-conjugated bile ...
Qi Zhao, Zilei Duan, Ren Lai, Pengcheng Ma   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Study on genetic rule of crude protein content in forage rapeseed plants

Siliao yanjiu
This study aimed to clarify the genetic rule of crude protein content in forage rapeseed plants, providing a theoretical foundation for the genetic improvement of high-protein forage rapeseed.
ZHANG Lin, ZHOU Ling, WANG Tao, ZHONG Wei, WU Yuyao, CHEN Jianjun, DAI Wendong   +6 more
doaj  

Green extraction of anthocyanins from Solanum betaceum peel by natural deep eutectic solvents: optimization, recycling, and evaluation of antioxidant, anti-inflammatory and skin-whitening activities

Frontiers in Sustainable Food Systems
This study developed a green and sustainable extraction method for anthocyanins from Solanum betaceum peel using choline chloride–based natural deep eutectic solvents (NADES).
Yaqian Yang, Ruiqi Liu, Yulei Qin, Jiashan Shen, Yangzhu Shi, Yizhe Cheng, Yizhe Cheng, Qiumin Lv   +7 more
doaj   +1 more source