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Mathematical models in genetics
Russian Journal of Genetics, 2016In this study, we present some of the basic ideas of population genetics. The founders of population genetics are R.A. Fisher, S. Wright, and J. B.S. Haldane. They, not only developed almost all the basic theory associated with genetics, but they also initiated multiple experiments in support of their theories.
M, Traykov, Iv, Trenchev
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British Journal of Psychiatry, 1976
SummaryAn analysis of recently published family history data on rapid eye movement (REM) narcolepsy was undertaken to determine the goodness-of-fit of a multifactorial (MF) model of inheritance. The analysis revealed that a two-threshold MF model can successfully account for the prevalence of REM narcolepsy and other disorders of excessive sleep (DES ...
J F, Leckman, E S, Gershon
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SummaryAn analysis of recently published family history data on rapid eye movement (REM) narcolepsy was undertaken to determine the goodness-of-fit of a multifactorial (MF) model of inheritance. The analysis revealed that a two-threshold MF model can successfully account for the prevalence of REM narcolepsy and other disorders of excessive sleep (DES ...
J F, Leckman, E S, Gershon
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Mathematical Proceedings of the Cambridge Philosophical Society, 1962
Wright (14), Feller (2) and others have proposed various stochastic models of genetics to study the fluctuations of gene frequency under the influence of mutation and selection. One of their simplest models has the following structure.
Karlin, S., McGregor, J.
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Wright (14), Feller (2) and others have proposed various stochastic models of genetics to study the fluctuations of gene frequency under the influence of mutation and selection. One of their simplest models has the following structure.
Karlin, S., McGregor, J.
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Genetic Models in Pathogenesis
Annual Review of Genetics, 2004▪ Abstract  To decipher the complexity of host-pathogen interactions the widest possible range of model hosts and of analytical methods is required. As some virulence mechanisms and certain host responses have been conserved throughout evolution, even simple organisms can be used as model hosts to help our understanding of infectious diseases.
Elizabeth, Pradel, Jonathan J, Ewbank
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Pharmacogenomics, 2002
The inference of genetic interactions from measured expression data is one of the most challenging tasks of modern functional genomics. When successful, the learned network of regulatory interactions yields a wealth of useful information. An inferred genetic network contains information about the pathway to which a gene belongs and which genes it ...
E P, van Someren +3 more
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The inference of genetic interactions from measured expression data is one of the most challenging tasks of modern functional genomics. When successful, the learned network of regulatory interactions yields a wealth of useful information. An inferred genetic network contains information about the pathway to which a gene belongs and which genes it ...
E P, van Someren +3 more
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Genetic models of carcinogenesis
Human Pathology, 1983The major genetic models of carcinogenesis are critically reviewed to determine their validity and relevance for clinical and experimental oncologists. Of major concern are the "two-hit" theory of Knudson and the host resistance system of Matsunaga. These models may be used to explain the pathobiologic peculiarities of human neoplasms, particularly ...
R P, Bolande, M J, Vekemans
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Genetic polymorphisms and additive genetic models
Behavior Genetics, 1985The degree of genetic dissimilarity between inbred strains or substrains of mice may be estimated from available data concerning biochemical and immunological polymorphisms. Dissimilarities between substrains are bimodally distributed, suggesting that both genetic drift and contamination are responsible for substrain differences.
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