Results 181 to 190 of about 2,522,601 (297)

Investigation of genetic polymorphisms associated with severe root resorption in orthodontic surgery patients. [PDF]

Braz Dent J
Schröder ÂGD, Kuczera MS, Araujo CM, Freitas VPS, Meger MN, Santos KMD, Scariot R, Küchler EC, Baratto-Filho F.   +8 more
europepmc   +1 more source

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

Advanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka, Azad Farzadfard, Jacob Aunstrup Larsen, Rasmus Krogh Norrild, Federica Saraceno, Celia Fricke, Hossein Mohammad‐Beigi, Ahmed Sadek, Jonas Folke, Susana Aznar, Alexander K. Buell   +10 more
wiley   +1 more source

Influence of genetic polymorphisms on omalizumab clinical response in pediatric severe asthma: a pilot study. [PDF]

Front Pharmacol
Rottura M, Pirrotta I, Cullotta C, Marino Y, Sacco FM, Gianguzzo VM, Irrera N, Arcoraci V, Alibrandi A, Galletta F, Corso M, Leonardi S, Manti S, Pallio G.   +13 more
europepmc   +1 more source

Genetic Polymorphism [PDF]

, 2020
openaire   +1 more source

Raman Analysis of RNA Nucleotide Strands From SARS‐CoV‐2 Variants and Subvariants: A Step Forward in the Definition of “Raman Genome”

Advanced Science, EarlyView.
Main Raman signals in RNA, related to helical backbone, ribofuranose ring, and nitrogenous bases, are affected by secondary structures that cause hyperchromic effects and significantly alter the Raman intensity. ABSTRACT Raman spectra of RNA nucleotide strands extracted from 20 SARS‐CoV‐2 strains, including the original Japanese isolate, Alpha, Beta ...
Giuseppe Pezzotti, Yoshiki Yasukochi, Gianluca Angiola, Takaharu Ueno, Saki Ikegami, Rintaro Okawa, Tetsuya Adachi, Wenliang Zhu, Osam Mazda, Alfio Grillo, Koichiro Higasa, Kazu Okuma   +11 more
wiley   +1 more source

Genetic Polymorphisms in Systemic Lupus Erythematosus and Their Clinical Implications: A Narrative Review. [PDF]

Int J Mol Sci
Egan AM, Johdi NA, Azizan EA, Mohd R, Rajalingham S, Shaharir SS, Zailani MAH.   +6 more
europepmc   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Host genetic polymorphisms, immune response, and susceptibility to pleural tuberculosis: A systematic review. [PDF]

J Clin Tuberc Other Mycobact Dis
Neto AA, Olivo TET, Mastroianni P, de Nadai MN, Forgerini M, de Nadai TR.   +5 more
europepmc   +1 more source

Transposable Element Dynamics Drive the Genomic Evolution and Phenotypic Diversification of Allotetraploid Common Carp

Advanced Science, EarlyView.
By integrating 516 whole‐genome resequencing datasets and 236 transcriptomes of allotetraploid common carp, this study establishes the first population‐scale atlas of transposable element (TE) variation in teleost species. TE bursts, relaxed purifying selection, and lineage‐specific loss of ancient insertions shape genome evolution and phenotypic ...
Shuimu Hu, Zhou Jiang, Lin Chen, Gowena Ling Yi Goh, Weijing Li, Qian He, Xintong Chen, Rui Li, Yuxuan Liu, Ning Li, Tao Zhou, Peng Xu   +11 more
wiley   +1 more source

<i>Helicobacter pylori</i> Vacuolating Cytotoxin A: Structure, Biological Functions, Genetic Polymorphisms, and Therapeutic Perspectives. [PDF]

Biomolecules
Song X, Tang X, Tay A, Benghezal M, Marshall BJ, Tang H, Li H.   +6 more
europepmc   +1 more source