Results 151 to 160 of about 320,413 (381)

Association of Human Leukocyte Antigen Alleles with COVID-19 Severity and Mortality in a Spanish Population

Medicina
Background and Objectives: The aim of the following cross-sectional study is to determine the association between human leukocyte antigen (HLA) alleles and outcomes in patients presenting to the emergency department (ED) with SARS-CoV-2 infection ...
Ester Lobato-Martinez, Javier Muriel-Serrano, Elena García-Payá, Pilar Gonzalez-de-la-Aleja, Raquel Garcia-Sevila, Mercedes Navarro-de-Miguel, Francisco Marco-de-la-Calle, Jose-Manuel Ramos-Rincon, Rosario Sanchez-Martinez   +8 more
doaj   +1 more source

Association between SNCA Intron and genetic predisposition to sporadic Parkinson's disease: a meta-analysis based on 49576 individuals [PDF]

, 2021
Peng Li, Zuqiang Fu, Lei Yan, Mingyang Du, Wei-guoLiu   +4 more
openalex   +1 more source

Akkermansia muciniphila‐Derived N‐Acetylspermidine Modulates the Localization of Intestinal α1,2‐Fucosylated Proteins to Maintain Gut Homeostasis

Advanced Science, EarlyView.
This study demonstrates that Akkermansia muciniphila alleviates colitis by enhancing intestinal α1,2‐fucosylation through its metabolite N‐acetylspermidine. Mechanistically, N‐acetylspermidine‐induced PIM1 inhibition promotes HDAC2‐mediated reduction of chromatin accessibility at TP73, thereby upregulating C1GALT1C1 to boost α1,2‐fucosylation.
Ye Yao, Zhangming Pei, Yuanyuan Dai, Yinghan Chen, Zepeng Chang, Hongchao Wang, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wenwei Lu, Wei Chen   +10 more
wiley   +1 more source

Agregación familiar en el síndrome de colon irritable en pacientes mexicanos. Un estudio de casos y controles

Atención Primaria
Resumen: Objetivo: Determinar la existencia de un patrón familiar de agregación del síndrome de intestino irritable (SII). Diseño: Es un estudio de casos y controles con proporción 1:2, llevado a cabo en una consulta externa de medicina general-familiar.
José M. Ramírez Aranda, Cinthya M. Martínez Gutiérrez, Mariano M. Fuentes Ramírez, Martín R. Escobedo Ríos, Fernanda del R. Delgado Cuevas   +4 more
doaj  

Genetic Bases for Predisposition to Common Multifactorial Disease in Man. Part II [PDF]

, 2007
Rumena Petkova, Stoyan Chakarov, Varban Ganev   +2 more
openalex   +1 more source

Integration of Genetic and Imaging Data for Alzheimer's Disease Diagnosis and Interpretation

Advanced Science, EarlyView.
AlzCLIP is a novel contrastive learning framework that integrates single nucleotide polymorphism (SNP) profiles and MRI‐derived imaging features into a unified representation space to improve Alzheimer's disease (AD) diagnosis and interpretation. By achieving superior diagnostic accuracy and revealing key genetic and structural contributors to AD risk,
Yanfei Wang, Qing Wang, Minghao Zhou, Jialu Liang, Lei You, Breton Asken, Xiaobo Zhou, Qianqian Song   +7 more
wiley   +1 more source

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

Advanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li   +12 more
wiley   +1 more source

Polymorphisms of methylenetetrahydrofolate reductase gene as the genetic predispositions of coronary artery diseases in eastern India [PDF]

, 2010
Soujatya Dhar, Sumana Chatterjee, Bani Sengupta, Shila Chakrabarti, Saumitra Ray, Anjanlal Dutta   +5 more
openalex   +1 more source

Genetic variability shapes the alternative pathway complement activity and predisposition to complement‐related diseases [PDF]

, 2022
Santiago Rodrı́guez de Córdoba
openalex   +1 more source

Zinc Alleviates Gut Barrier Dysfunction by Promoting the Methylation of AKT

Advanced Science, EarlyView.
Zinc activates the ZNG1‐METAP1 complex to elevate intracellular SAM levels, which promotes PRMT5‐mediated symmetrical dimethylation of AKT at R391 and R15. This epigenetic modification facilitates AKT membrane translocation and mTORC2 activation, thereby enhancing epithelial proliferation and gut barrier integrity.
Chuanjiang Cai, Yining Zheng, Bo Sun, Guoyan Wang, Pengfei Li, Huijun Geng, Rongnuo Li, Miaomiao Zhu, Yuanyuan Zhu, Dingping Feng, Lei Chen, Guiyan Chu, Lu Deng, Shiyan Qiao   +13 more
wiley   +1 more source