Results 211 to 220 of about 319,093 (308)

Genetic and Clinical Determinants of Chronic Thromboembolic Pulmonary Hypertension: The Role of PAI-1 Polymorphism. [PDF]

Int J Mol Sci
Batum Ö, Ayık Türk M, Varol Y, Özyılmaz B, Akarçay AE, Dirican N, Doruk S, Deniz S.   +7 more
europepmc   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Clinical, genetic, and familial features of POT1 tumor predisposition syndrome. [PDF]

Cancer
DiNardo CD, Croden J, Abdel-Salam HM, Kadia T, Molica M, Bazinet A, Bose P, Maiti A, Haddad F, Burger J, Kantarjian H, Wierda W, Jain N, Ferrajoli A.   +13 more
europepmc   +1 more source

Sjögren Disease—B Cells at the Brink: From Autoimmunity to Lymphomagenesis and the Rise of Novel B Cell–Targeted Therapies

Arthritis &Rheumatology, EarlyView.
Sjögren disease (SjD) is a common systemic autoimmune disorder characterized by inflammation of the exocrine glands, resulting in dryness. Patients frequently exhibit extraglandular manifestations affecting various organ systems. To date, there are no US Food and Drug Administration (FDA)‐approved disease‐modifying therapies for SjD. In this review, we
Rachael A. Gordon, Sara S. McCoy
wiley   +1 more source

Dental Rehabilitation of a Child Diagnosed With Alopecia Areata Totalis: A Case Report. [PDF]

Cureus
Abou Samra N, Aboujaoude S.
europepmc   +1 more source

Interleukin‐5, Eosinophils, and Interleukin‐5 Pathway Inhibitors in Eosinophilic Granulomatosis With Polyangiitis

Arthritis &Rheumatology, EarlyView.
Interlukin‐5 (IL‐5) plays a crucial role in the pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) by promoting eosinophil differentiation, activation, and survival. We present here a typical case of EGPA in which treatment with IL‐5 pathway inhibitors is prescribed, showing to be beneficial for the patient.
Alvise Berti, Christian Pagnoux
wiley   +1 more source

Risk in Repose: Sedentary Behavior and Genetic Susceptibility to Cardiovascular Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
James Sawalla Guseh, Ezimamaka C. Ajufo
doaj   +1 more source

Genetic variants associated with systemic inflammatory disease associate with temporomandibular symptoms with or without periodontitis. [PDF]

PLoS One
Lucas C, Baxter D, Deeley K, Shah N, Pugliano A, Silva R, Letra A, Bezamat M, Almarza A, Taboas J, Vieira AR.   +10 more
europepmc   +1 more source

Single‐Cell RNA Sequencing Informs Precision Targeting of Monogenic Lupus Associated With IKZF1 Haploinsufficiency

Arthritis &Rheumatology, EarlyView.
Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng, Yejun Tan, Zhaoling Wang, Yanjie Qian, Qian Ma, Danping Shen, Meiping Lu   +6 more
wiley   +1 more source

Polygenic prediction of coronary heart disease among 130 000 Mexican adults. [PDF]

Eur J Prev Cardiol
Liu T, Berumen J, Torres J, Alegre-Díaz J, Baca P, González-Carballo C, Ramirez-Reyes R, Rivas F, Aguilar-Ramirez D, Bragg F, Herrington W, Hill M, Trichia E, Vergara-Lope A, Wade R, Collins R, Kuri-Morales P, Emberson JR, Tapia-Conyer R, Gnatiuc Friedrichs L.   +19 more
europepmc   +1 more source