Results 81 to 90 of about 208,174 (208)

Living with Risk, Aging with Uncertainty: A Narrative Review of Health and Genetic Vulnerability in Huntington’s Disease

Biomedicines
Background/Objectives: Huntington’s disease (HD) is an autosomal dominant, neurodegenerative disorder that, because of the availability of presymptomatic genetic testing, places at-risk individuals in an anticipatory situation of great emotional, ethical,
Adriana V. Muñoz-Ortega, David Conde Caballero, Lorenzo Mariano Juárez   +2 more
doaj   +1 more source

Unravelling the Genetics of Ischaemic Stroke

, 2010
Epidemiological studies suggest genetic predisposition is important in stroke risk. Monogenic conditions are important for the individual patient but do not account for much population attributable risk. An increasing number of such conditions are being
Hugh S Markus, Markus Hugh S., Markus, HS   +2 more
core   +1 more source

Aspectos genéticos do transtorno obsessivo-compulsivo

Brazilian Journal of Psychiatry, 2001
Since the first descriptions of obsessive-compulsive disorder (OCD), genetic factors have been implicated in the etiology of the illness. Twin studies show a high concordance rate for monozygotic twins.
Gonzalez Christina H
doaj  

Genome-wide analysis of genetic predisposition to Alzheimer’s disease and related sex disparities

Alzheimer’s Research & Therapy, 2019
Background Alzheimer’s disease (AD) is the most common cause of dementia in the elderly and the sixth leading cause of death in the United States. AD is mainly considered a complex disorder with polygenic inheritance.
Alireza Nazarian, Anatoliy I. Yashin, Alexander M. Kulminski   +2 more
doaj   +1 more source

Dietary management and genetic predisposition

, 2013
Today, dietary recommendations are based on recommended daily intake for the general population, and only a few subgroups are considered for additional dietary advice. Nutrigenetics aim to optimize health and prevent disease.
Jensen, Hanne Holbæk, Larsen, Lesli Hingstrup   +1 more
core   +1 more source

Skin microvascular vasodilatory capacity in offspring of two parents with Type 2 diabetes [PDF]

, 2001
Aims<br/> Microvascular dysfunction occurs in Type 2 diabetes and in subjects with fasting hyperglycaemia. It is unclear whether this dysfunction relates to dysglycaemia.
Shore, A.C., Lowe, G.D., Lee, B.C., B. C. Lee, Clark, P.M., A. Rumley, J. E. Tooke, A. T. Hattersley, Rumley, A., Tooke, J.E., G. D. Lowe, A. C. Shore, J. M. Humphreys, Humphreys, J.M., P. M. Clark, Hattersley, A.T.   +15 more
core   +1 more source

Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins

BMC Cancer, 2011
Background Colorectal cancer (CRC) is the second leading cause of cancer death in developed countries. Familial aggregation in CRC is also important outside syndromic forms and, in this case, a polygenic model with several common low-penetrance alleles ...
Moreno Victor, Villanueva Cristina M, Carvajal-Carmona Luis, Llor Xavier, Xicola Rosa M, Jover Rodrigo, Payá Artemio, Riestra Sabino, Peña Elena, Fernández-Bañares Fernando, Rigau Joaquim, Latorre Mercedes, Morillas Juan D, Cubiella Joaquin, González Dolors, Clofent Joan, Bessa Xavier, Gonzalo Victoria, Muñoz Jenifer, Alonso-Espinaco Virginia, Fernández-Rozadilla Ceres, Abulí Anna, Piqué Josep M, Carracedo Angel, Castells Antoni, Andreu Montserrat, Ruiz-Ponte Clara, Castellví-Bel Sergi   +27 more
doaj   +1 more source

Genetic predisposition for cervical cancer

, 2020
Aim: to assess a role of genetic factors and human papillomavirus (HPV) in developing cervical neoplasia based on analyzing current publications on virus-induced carcinogenesis.Materials and methods.
T. V. Rotaru, N. P. Lapochikina, L. I. Rotaru   +2 more
core   +1 more source

Genetic predisposition to periodontal disease: A review

Genetika
Periodontal disease is a complex, multifactorial disease and the predisposition to its occurrence is genetically determined. A multitude of research projects on genotyping of patients and controls in search of putative genetic risk factors has been performed.
Ana Pejcic, Ivan Minic, Milena Kostic, Marija Bradic-Vasic, Dzemil Kurtagic   +4 more
openaire   +1 more source

Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: Pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take "toll"?

, 2006
The pathogenesis of inflammatory bowel disease (IBD) is only partially understood. Various environmental and host (e.g. genetic-, epithelial-, immune and non-immune) factors are involved.
Papp, János, Lakatos, Péter László, Fischer, Simon, Lakatos, László, Gál, István   +4 more
core