Results 51 to 60 of about 174,883 (339)

Diphthamide synthesis is linked to the eEF2‐client chaperone machinery

FEBS Letters, EarlyView.
The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr, Klaus Mayer, Raffael Schaffrath, Johannes Buchner, Ulrich Brinkmann   +4 more
wiley   +1 more source

Tactics Exploration Framework based on Genetic Programming

International Journal of Computational Intelligence Systems, 2017
Engagement-level simulation is a quantitative way to evaluate the effectiveness of weapon systems before construction and acquisition, minimizing the risk of investment. Though contractors have built simulation systems with high fidelity models of weapon
Jian Yao, Weiping Wang, Zhifei Li, Yonglin Lei, Qun Li   +4 more
doaj   +1 more source

Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase

FEBS Letters, EarlyView.
Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka, Takahiro Ogawa, Rikako Tsukida, Keiichi Noguchi, David Hibbett, Yoko Katayama, Makoto Yoshida   +6 more
wiley   +1 more source

Elucidation of interface interactions between a dehydratase domain and an acyl carrier protein in cremimycin polyketide synthase

FEBS Letters, EarlyView.
In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri, Haruka Tachibana, Daisuke Kawasaki, Taichi Chisuga, Toma Kashima, Shinya Fushinobu, Fumitaka Kudo, Tadashi Eguchi, Akimasa Miyanaga   +8 more
wiley   +1 more source

Application of the evolutionary approach to structural and parametric identification of dynamic objects [PDF]

ITM Web of Conferences
The paper examines the evolutionary approach to structural and parametric identification of dynamic systems in the form of differential equations. The approach is based on a genetic programming algorithm to determine a structure of the equation and ...
Karaseva Tatiana
doaj   +1 more source

Bandit-Based Genetic Programming [PDF]

, 2010
We consider the validation of randomly generated patterns in a Monte-Carlo Tree Search program. Our bandit-based genetic programming (BGP) algorithm, with proved mathematical properties, outperformed a highly optimized handcrafted module of a well-known computer-Go program with several world records in the game of Go.
Hoock, Jean-Baptiste, Teytaud, Olivier
openaire   +5 more sources

Expressive Genetic Programming [PDF]

Proceedings of the 2016 on Genetic and Evolutionary Computation Conference Companion, 2016
The language in which evolving programs are expressed can have significant impacts on the dynamics and problem-solving capabilities of a genetic programming system. In GP these impacts are driven by far more than the absolute computational power of the languages used; just because a computation is theoretically possible in a language, it doesn't mean ...
Nicholas Freitag McPhee, Lee Spector
openaire   +2 more sources

Bounding bloat in genetic programming [PDF]

Proceedings of the Genetic and Evolutionary Computation Conference, 2017
While many optimization problems work with a fixed number of decision variables and thus a fixed-length representation of possible solutions, genetic programming (GP) works on variable-length representations. A naturally occurring problem is that of bloat (unnecessary growth of solutions) slowing down optimization. Theoretical analyses could so far not
Johannes Lengler, Benjamin Doerr, J. A. Gregor Lagodzinski, Timo Kötzing   +3 more
openaire   +3 more sources

Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions

FEBS Letters, EarlyView.
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten, Lorenz Schwaiger, Zarah Forsberg, Kelsi R. Hall, Anton A. Stepnov, Tom Z. Emrich‐Mills, Iván Ayuso‐Fernández, Morten Sørlie, Roland Ludwig, Åsmund Kjendseth Røhr, Vincent G. H. Eijsink   +10 more
wiley   +1 more source

Estimation Models Generation using Linear Genetic Programming

CLEI Electronic Journal, 2009
The use of decision rules and estimation techniques is increasingly common for decision mak- ing. In recent years studies were conducted which applies Genetic Programming (GP) to obtain rules to make predictions.
Javier Martínez Canillas, Roberto Sánchez, Benjamín Barán   +2 more
doaj   +1 more source