Results 51 to 60 of about 377,378 (213)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Cartesian genetic programming for trading: a preliminary investigation [PDF]

, 2012
In this paper, a preliminary investigation of Cartesian Genetic Programming (CGP) for algorithmic intraday trading is conducted. CGP is a recent new variant of genetic programming that differs from traditional approaches in a number of ways, including ...
Mayo, Michael
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Genetic programming in data mining for drug discovery [PDF]

, 2004
Genetic programming (GP) is used to extract from rat oral bioavailability (OB) measurements simple, interpretable and predictive QSAR models which both generalise to rats and to marketed drugs in humans. Receiver Operating Characteristics (ROC) curves
Barrett, S.J., Langdon, W.B.
core   +2 more sources

Application of Genetic Programming to High Energy Physics Event Selection

, 2005
We review genetic programming principles, their application to FOCUS data samples, and use the method to study the doubly Cabibbo suppressed decay D+ -> K+ pi+ pi- relative to its Cabibbo favored counterpart, D+ -> K- pi+ pi+. We find that this technique
A. Cerutti, A. Kryemadhi, A. Massafferri, A. Paris, A. Rahimi, A. Sánchez-Hernández, A. Zallo, A.A. Machado, A.C. dos Reis, A.E. Kreymer, A.M. Lopez, B. O’Reilly, B.R. Ko, Banzhaf, C. Castromonte, C. Cawlfield, C. Göbel, C. Pontoglio, C. Riccardi, C. Uribe, Cranmer, D. Engh, D. Lopes Pegna, D. Menasce, D. Pantea, D. Pedrini, D.Y. Kim, E. Casimiro, E. Cuautle, E. Gottschalk, E. Luiggi, E. Polycarpo, E.W. Vaandering, F. Leveraro, F. Prelz, F. Vázquez, F.L. Fabbri, Frabetti, Frabetti, G. Alimonti, G. Boca, G. Bonomi, G. Chiodini, G. Gianini, G. Liguori, H. Hernandez, H. Mendez, H. Park, H.W.K. Cheung, Hagiwara, I. Bediaga, I. Gaines, I. Segoni, I.M. Pepe, J. Magnin, J. Quinones, J. Wiss, J.C. Anjos, J.E. Moore, J.E. Ramirez, J.M. de Miranda, J.M. Link, J.N. Butler, J.P. Cumalat, J.R. Wilson, J.S. Kang, J.W. Kwak, K. Cho, K. Stenson, K.B. Lee, Koza, L. Agostino, L. Benussi, L. Cinquini, L. Edera, L. Moroni, L.A. Garren, Link, Link, Link, Link, Link, M. Bertani, M. Boschini, M. DiCorato, M. Hosack, M. Mezzadri, M. Nehring, M. Reyes, M. Rovere, M. Sheaff, M. Wang, M. Webster, M.M. Merlo, P. Dini, P. D’Angelo, P. Inzani, P. Vitulo, P.D. Sheldon, P.H. Garbincius, P.H. Kasper, P.M. Yager, R. Gardner, R. Kutschke, R. Mitchell, S. Barberis, S. Bianco, S. Carrillo, S. Erba, S. Malvezzi, S. Pacetti, S. Sala, S.P. Ratti, T. Handler, T.F. Davenport, V. Arena, W.E. Johns, Wall, Y. Zhang, Y.S. Chung   +119 more
core   +5 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

A Genetic Programming Approach to Geometrical Digital Content Modeling in Web Oriented Applications [PDF]

The paper presents the advantages of using genetic techniques in web oriented problems. The specific area of genetic programming applications that paper approaches is content modeling.
Dragos PALAGHITA
core