Results 71 to 80 of about 116,877 (316)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
A Genetic Programming Problem Definition Language Code Generator for the EpochX Framework [PDF]
, 2014 There are many different genetic programming (GP) frameworks that can be used to implement algorithms to solve a particular optimization problem. In order to use a framework, users need to become familiar with a large numbers of source code before ...
Leroux, Claris +5 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
The structure of the genetic programming collaboration network
, 2006 The genetic programming bibliography aims to be the most complete reference of papers on genetic programming. In addition to locating publications, it contains coauthor and coeditor relationships which have not previously been studied.
Luthi, Leslie +3 more
core +1 more source
Genetic programming for knowledge discovery in chest pain diagnosis [PDF]
, 2000 This work aims at discovering classification rules for diagnosing certain pathologies. These rules are capable of discriminating among 12 different pathologies, whose main symptom is chest pain.
Bojarczuk, Celia C. +5 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Evolving Matrix-Factorization-Based Collaborative Filtering Using Genetic Programming
Applied Sciences, 2020 Recommender systems aim to estimate the judgment or opinion that a user might offer to an item. Matrix-factorization-based collaborative filtering typifies both users and items as vectors of factors inferred from item rating patterns.
Raúl Lara-Cabrera +3 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source