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Initiation of genetic recombination and recombination-dependent replication
Trends in Biochemical Sciences, 2000Recombination initiates at double-stranded DNA breaks and at single-stranded DNA gaps. These DNA strand discontinuities can arise from DNA-damaging agents and from normal DNA replication when the DNA polymerase encounters an imperfection in the DNA template or another protein.
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MOLECULAR MECHANISMS IN GENETIC RECOMBINATION
Annual Review of Genetics, 1973Genetic recombination is the set of processes that results in new linkage relationships of genes or parts of genes (l), Three subclasses of recombination are currently recognized: (a) General recombination describes exchanges that occur between homologous genophores, more or less anywhere along their length.
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Molecular Aspects of Genetic Recombination
1971Publisher Summary This chapter reviews that recombination is synonymous with genetic analysis. It has been implicated in ensuring the accuracy of chromosome segregation during meiosis, as a device to circularize bacteriophage chromosomes as a prelude to their replication, in the initiation of the state of molecular parasitism for temperate phages ...
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Genetic Recombination in RNA Viruses
1992Recombination in RNA viruses involves the exchange of genetic information between two nonsegmented RNA genomes, as distinct from the reassortment of RNA seen in viruses containing segmented genomes. The mechanism of RNA recombination appears to be similar to the generation of defective interfering (DI) RNA, since they both involve polymerase jumping ...
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