Results 61 to 70 of about 2,453,394 (283)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Recombination modulates how selection affects linked sites in Drosophila [PDF]

, 2012
One of the most influential observations in molecular evolution has been a strong association between regional recombination rate and amount of nucleotide polymorphism in those genomic regions, interpreted as evidence for ubiquitous natural selection ...
Caiti S. Smukowski, Tiffany L. Himmel, Suzanne McGaugh, Tiffany Himmel, Mohamed A. F. Noor, Brenda Manzano-Winkler, Caiti Smukowski, Suzanne E. McGaugh, Mohamed Noor   +8 more
core   +1 more source

Probable Mechanisms of COVID-19 Pathogenesis

Креативная хирургия и онкология, 2020
This review paper focuses on the search for innovative directions in the study of COVID­19 viral infection with the purpose of improving the methods of its treatment and vaccination.
R. N. Mustafin, E. K. Khusnutdinova
doaj   +1 more source

Indirect stimulation of genetic recombination [PDF]

Proceedings of the National Academy of Sciences, 1983
Recombination between lac Z alleles in crosses of λ lac Z 1 - × λ lac Z 2 - and F
E I, Golub, K B, Low
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

High-resolution genotyping and mapping of recombination and gene conversion in the protozoan Theileria parva using whole genome sequencing [PDF]

, 2012
BACKGROUND: Theileria parva is a tick-borne protozoan parasite, which causes East Coast Fever, a disease of cattle in sub-Saharan Africa. Like Plasmodium falciparum, the parasite undergoes a transient diploid life-cycle stage in the gut of the arthropod ...
Spooner Paul R, Ulrich Certa, Pelle, R., Richard P Bishop, Ebeling, M., Pelle Roger, Lucy Poveda, Roger Pelle, Küng, Erich, Morzaria, S., Henson, Sonal, Morzaria, S.P., Erich Küng, Bishop, Richard P., Daubenberger, C.A., Daubenberger, Claudia A., Certa, U., Spooner, Paul R, Poveda, Lucy, Paul R Spooner, Poveda, L., Ebeling, Martin, Certa, Ulrich, Claudia A Daubenberger, Spooner, P.R., Weihong Qi, Sonal Henson, Bishop Richard P, Spooner, Paul R., Certa Ulrich, Henson Sonal, Henson, S., Morzaria Subhash, Qi Weihong, Poveda Lucy, Subhash Morzaria, Bishop, R. P., Spooner, P. R., Kung, E., Pelle, Roger, Ebeling Martin, Küng Erich, Daubenberger Claudia A, Morzaria, Subhash, Daubenberger, C. A., Bishop, Richard P, Martin Ebeling, Qi, W., Qi, Weihong, Daubenberger, Claudia A   +49 more
core   +1 more source

Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe

Emerging Infectious Diseases, 2021
In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016–2018.
Kimberley S.M. Benschop, Eeva K. Broberg, Emma Hodcroft, Dennis Schmitz, Jan Albert, Anda Baicus, Jean-Luc Bailly, Gudrun Baldvinsdottir, Natasa Berginc, Soile Blomqvist, Sindy Böttcher, Mia Brytting, Erika Bujaki, Maria Cabrerizo, Cristina Celma, Ondrej Cinek, Eric C.J. Claas, Jeroen Cremer, Jonathan Dean, Jennifer L. Dembinski, Iryna Demchyshyna, Sabine Diedrich, Susanne Dudman, Jake Dunning, Robert Dyrdak, Mary Emmanouil, Agnes Farkas, Cillian De Gascun, Guillaume Fournier, Irina Georgieva, Ruben Gonzalez-Sanz, Jolanda van Hooydonk-Elving, Anne J. Jääskeläinen, Ruta Jancauskaite, Kathrin Keeren, Thea K. Fischer, Sidsel Krokstad, Lubomira Nikolaeva–Glomb, Ludmila Novakova, Sofie E. Midgley, Audrey Mirand, Richard Molenkamp, Ursula Morley, Joël Mossong, Svajune Muralyte, Jean-Luc Murk, Trung Nguyen, Svein A. Nordbø, Riikka Österback, Suzan Pas, Laura Pellegrinelli, Vassiliki Pogka, Birgit Prochazka, Petra Rainetova, Marc Van Ranst, Lieuwe Roorda, Isabelle Schuffenecker, Rob Schuurman, Asya Stoyanova, Kate Templeton, Jaco J. Verweij, Androniki Voulgari-Kokota, Tytti Vuorinen, Elke Wollants, Katja C. Wolthers, Katherina Zakikhany, Richard Neher, Heli Harvala, Peter Simmonds   +68 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Genetic characterization of Pepino mosaic virus isolates from Belgian greenhouse tomatoes reveals genetic recombination [PDF]

, 2008
Over a period of a few years, Pepino mosaic virus (PepMV) has become one of the most important viral diseases in tomato production worldwide. Infection by PepMV can cause a broad range of symptoms on tomato plants, often leading to significant financial ...
Wittemans, Lieve, Paeleman, A., Thomma, B.P.H.J., Paeleman, Anneleen, Vanachter, Alfons C. R. C., Goen, K., Hanssen, Inge M., Lievens, Bart, Hanssen, I.M., Bragard, C., Wittemans, L.P.F., Vanachter, A.C.R.C., Vanachter, Alfons C.R.C., Thomma, Bart P.H.J., Bragard, Claude, Groen, Kris, Goen, Kris, Thomma, Bart P. H. J., Lievens, B.   +18 more
core   +1 more source

Intraspecific genetic diversity of the fish-infecting microsporidian parasite Pseudokabatana alburnus (Microsporidia)

Frontiers in Microbiology, 2023
Pseudokabatana alburnus is a xenoma-forming fish microsporidium, firstly described from the liver of the Culter alburnus from Poyang Lake in China. In the present study, P.
Meiqi Weng, Meiqi Weng, Meiqi Weng, Xintong Zhang, Zhaozhe Xin, Sijia Xue, Qianqian Zhang, Aihua Li, Jinyong Zhang, Jinyong Zhang   +9 more
doaj   +1 more source