Results 41 to 50 of about 348,845 (266)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Single-crossover recombination and ancestral recombination trees

, 2011
von Wangenheim U. Single-crossover recombination and ancestral recombination trees. Bielefeld: Universität Bielefeld; 2011.Modeling the process of recombination in the deterministic limit of an infinite population leads to a large coupled nonlinear ...
von Wangenheim, Ute
core  

Recombination modulates how selection affects linked sites in Drosophila

, 2012
One of the most influential observations in molecular evolution has been a strong association between regional recombination rate and amount of nucleotide polymorphism in those genomic regions, interpreted as evidence for ubiquitous natural selection ...
Caiti S. Smukowski, Tiffany L. Himmel, Suzanne McGaugh, Tiffany Himmel, Mohamed A. F. Noor, Brenda Manzano-Winkler, Caiti Smukowski, Suzanne E. McGaugh, Mohamed Noor   +8 more
core   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Evidence for RNA recombination between distinct isolates of Pepino mosaic virus.

, 2010
Genetic recombination plays an important role in the evolution of virus genomes. In this study we analyzed publicly available genomic sequences of Pepino mosaic virus (PepMV) for recombination events using several bioinformatics tools.
Leunissen, Jack, Kuzniar, A., Hasiów-Jaroszewska, B., Peters, S.A., Peters, Sander, Leunissen, J.A.M., Pospieszny, Henryk, Hasiów-Jaroszewska, Beata, Kuzniar, Arnold, Pospieszny, H.   +9 more
core  

Genetic characterization of Pepino mosaic virus isolates from Belgian greenhouse tomatoes reveals genetic recombination

, 2008
Over a period of a few years, Pepino mosaic virus (PepMV) has become one of the most important viral diseases in tomato production worldwide. Infection by PepMV can cause a broad range of symptoms on tomato plants, often leading to significant financial ...
Wittemans, Lieve, Paeleman, A., Thomma, B.P.H.J., Paeleman, Anneleen, Vanachter, Alfons C. R. C., Goen, K., Hanssen, Inge M., Lievens, Bart, Hanssen, I.M., Bragard, C., Wittemans, L.P.F., Vanachter, A.C.R.C., Vanachter, Alfons C.R.C., Thomma, Bart P.H.J., Bragard, Claude, Groen, Kris, Goen, Kris, Thomma, Bart P. H. J., Lievens, B.   +18 more
core   +1 more source

Bayesian modeling of recombination events in bacterial populations [PDF]

, 2008
Background: We consider the discovery of recombinant segments jointly with their origins within multilocus DNA sequences from bacteria representing heterogeneous populations of fairly closely related species.
Marttinen, P., Hanage William P, Mahenthiralingam Eshwar, Adam Baldwin, Jukka Corander, Marttinen Pekka, Hanage, William P., Pekka Marttinen, Hanage, W. P., Marttinen, Pekka, Dowson, Christopher G., Baldwin, A., Baldwin Adam, Dowson, C., Chris Dowson, Corander, J., Baldwin, Adam, Dowson Chris, William P Hanage, Eshwar Mahenthiralingam, Corander Jukka, Mahenthiralingam, Eshwar   +21 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Determinants of selectivity in Xer site-specific recombination

, 1996
A remarkable property of some DNA-binding proteins that can interact with and pair distant DNA segments is that they mediate their biological function only when their binding sites are arranged in a specific configuration. Xer site-specific recombination
Blakely, G, Sherratt, D
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source