Results 191 to 200 of about 5,434,712 (302)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Pathological microenvironment-responsive nano-glycospheres restore disc homeostasis by combinatorial metabolic and genetic regulation. [PDF]

J Nanobiotechnology
Zhao L, Ma W, Wang W, Zhou D, Fan J, Liu M, Liu L, Huang L, Wei X, Zheng Z, Liu H, Wu D.   +11 more
europepmc   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Genetic regulation of methylation across East Asian and European populations. [PDF]

Nat Commun
Liu R, Chen TT, Xia Y, Lin SC, Ge T, Chen CY, Feng YA, Huang H, Lin YF.   +8 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Long non-coding RNA profile in genetic symptomatic and presymptomatic frontotemporal dementia : a GENFI study

: BACKGROUND Long non-coding RNAs (lncRNAs) play crucial roles in gene regulation and are implicated in neurodegenerative diseases, including frontotemporal dementia (FTD).
Masellis, Mario, Foster, Phoebe H., Graff, Caroline, Rotondo, Emanuela, Ferry-Bolder, Eve, Ghezzi, Laura, Jiskoot, Lize C., Sacchi, Luca, Gerhard, Alexander, Bouzigues, Arabella, Seelaar, Harro, Santana, Isabel, Butler, Chris R., Tartaglia, Maria Carmela, Arighi, Andrea, Le Ber, Isabelle, Russell, Lucy L., Laforce, Robert, Synofzik, Matthis, Borracci, Vittoria, Galimberti, Daniela, Fenoglio, Chiara, Moreno, Fermin, Ducharme, Simon, Sorbi, Sandro, Finger, Elizabeth, Pintus, Manuela, S\ue1nchez Valle, Raquel, Pasquier, Florence, Levin, Johannes, Rowe, James B., de Mendon\ue7a, Alexandre, Otto, Markus, Arcaro, Marina, Tiraboschi, Pietro, Rohrer, Jonathan D., Bruffaerts, Rose, Carandini, Tiziana, Genetic FTD Initiative GENFI, Borroni, Barbara, van Swieten, John C., Serpente, Maria, Vandenberghe, Rik   +42 more
core  

Rice Quality: A Multidimensional Evaluation Integrating Ecology, Management and Genetic Regulation. [PDF]

Foods
Huang W, Shi D, Cheng A, Chen G, Liu F, Dong J, Lan J, Guo W, Liu B, Ren C.   +9 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Comparative Single-Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits. [PDF]

Adv Sci (Weinh)
Zhao B, Luo H, Guan D, Fu X, Wang F, Zhang G, Li S, Yang H, Zhang Y.   +8 more
europepmc   +1 more source