Results 221 to 230 of about 5,434,712 (302)

Vascular normalization confers an endothelial immune suppressive gene expression profile

Molecular Oncology, EarlyView.
We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley   +1 more source

Correction for Zhang et al., Host genetic regulation of rumen 6-hydroxymelatonin reduces methane emissions in dairy cattle. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Multi-omics dissection of the genetic regulation underlying fatty acid composition in cattle. [PDF]

Genome Biol
Zhang T, Niu Q, Wang T, Wu J, Zhu B, Wang Z, Gao X, Chen Y, Gao H, Zhang L, Fu T, Gao T, Liu GE, Li J, Xu L.   +14 more
europepmc   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk. [PDF]

Adv Sci (Weinh)
Wang X, Geng H, Yao Z, Jiang Y, Chen C, Lu Z, Tian S, Zhang M, Liu R, Feng C, Li B, Miao X, Tian J, Zhang S, Zhu Y.   +14 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

The foliar potassium silicate enhances wheat terminal-drought tolerance and yield via physiological, biochemical and genetic regulation. [PDF]

Front Plant Sci
Alzahrani Y, Alsamadany H, Shah ZH.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Genetic regulation across germline and somatic variation on the Y chromosome contributes to type 2 diabetes. [PDF]

Nat Med
Sato G, Yamamoto Y, Sonehara K, Saiki R, Ojima T, Kanai M, Liu A, Edahiro R, Shirai Y, Namba S, Namkoong H, Hasaegawa T, Koyanagi YN, Kasugai Y, Yamaji T, Nakano S, Genovese G, Sipilä TP, Ghazal A, Tanaka H, Azekawa S, Uwamino Y, Yamamoto K, Suzuki K, Hata T, Uemura M, Takeda Y, Kanai A, Higashiue S, Kobayashi S, Afuso H, Matsuura K, Mitsumoto Y, Fujita Y, FinnGen, Japan COVID-19 Task Force, Biobank Japan Project, Oda Y, Suzuki Y, Morisaki T, Ishii M, Kitagawa Y, Koike R, Kimura A, Imoto S, Miyano S, Kanai T, Takayama J, Iwasaki M, Sawada N, Fukunaga K, Matsuo K, Kumanogoh A, Doki Y, Eguchi H, Nakagome S, Tamiya G, Ganna A, Palotie A, Daly MJ, Wilson JF, Yamamoto M, Matsuda K, Ogawa S, Yamauchi T, Kadowaki T, Okada Y.   +66 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source