Results 231 to 240 of about 445,590 (261)

Genetic Risk Scores

Current Protocols in Human Genetics, 2016
AbstractThe generation of genome‐wide variation data has become commonplace. However, the potential for interpretation and application of these data for clinical assessment of outcomes of interest, and prediction of disease risk, is currently not fully realized.
Jessica N, Cooke Bailey, Robert P, Igo
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Genetic risk scores in lipid disorders

Current Opinion in Cardiology, 2019
Extensive work has gone into understanding the genetics of cardiovascular disease (CVD) and implicating genes involved in hyperlipidaemia. Translation into routine practise involves using genetic risk scores (GRS) to identify high-risk individuals in the general population.
Anthony S, Wierzbicki, Timothy M, Reynolds   +1 more
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Genetic risk score is associated with T2DM and diabetes complications risks

Gene, 2023
Type 2 diabetes mellitus (T2DM) is a prototypical complex disease with polygenic architecture playing an important role in determining susceptibility to develop the disease (and its complications) in subjects exposed to modifiable lifestyle factors. A current challenge is to quantify the degree of the individual's genetic risk using genetic risk scores
Jaroslav A, Hubacek, Lucie, Dlouha, Vera, Adamkova, Dana, Dlouha, Lukas, Pacal, Katerina, Kankova, David, Galuska, Vera, Lanska, Jiri, Veleba, Terezie, Pelikanova   +9 more
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Development of a genetic risk score for obesity predisposition evaluation

Molecular Genetics and Genomics, 2022
Obesity is a major public health issue resulting from an interaction between genetic and environmental factors. Genetic risk scores (GRSs) are useful to summarize the effects of many genetic variants on obesity risk. In this study, we aimed to assess the association of previously well-studied genetic variants with obesity and develop a genetic risk ...
Narges, Damavandi, Armin, Soleymaniniya, Sobhan, Bahrami Zadegan, Mohammad Hasan, Samiee Aref, Sirous, Zeinali   +4 more
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Genetic risk score for gestational weight gain

European Journal of Obstetrics & Gynecology and Reproductive Biology
Gestational weight gain (GWG) involves health consequences for both mother and offspring. Genetic factors seem to play a role in the GWG trait. For small effect sizes of a single genetic polymorphism (SNP), a genetic risk score (GRS) summarizing risk-associated variation from multiple SNPs can serve as an effective approach to genetic association ...
Joanna Mikołajczyk-Stecyna, Ewelina Zuk, Agnieszka Seremak-Mrozikiewicz, Grażyna Kurzawińska, Hubert Wolski, Krzysztof Drews, Agata Chmurzynska   +6 more
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Creating a genetic risk score for coronary artery disease

Current Atherosclerosis Reports, 2009
Coronary artery disease (CAD) and its sequelae represent a significant health burden. Over the past two decades, numerous studies have attempted to link DNA sequence variation with the risk of CAD and related phenotypes. There has been significant evolution in technology from the early linkage studies within kindreds, and now we are able to use high ...
Sonny, Dandona, Robert, Roberts
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Polygenic Risk Scores and Genetics in Psychiatry

American Journal of Psychiatry, 2022
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Performance of individual and joint risk stratification by an environmental risk score and a genetic risk score in a colorectal cancer screening setting

International Journal of Cancer, 2020
Hauke Thomsen, , Yesilda Balavarca
exaly  

Refining Genetic Risk Scores

Clinical OMICs, 2019
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