Results 161 to 170 of about 2,212,354 (298)

Advancing Genetic Selection and Behavioral Genomics of Working Dogs Through Collaborative Science. [PDF]

Front Vet Sci, 2021
Chen FL, Zimmermann M, Hekman JP, Lord KA, Logan B, Russenberger J, Leighton EA, Karlsson EK.   +7 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Development of a health subindex for genetic selection of bulls and cows in Canadian dairy operations. [PDF]

JDS Commun
Bjelland DW, Crowley JJ, Richardson CM, Howes N, Amer PR, Fleming A, Jaton C, Baes CF, Miglior F.   +8 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Analysis of genetic selection at insulin receptor substrate-2 gene loci. [PDF]

J Diabetes Metab Disord, 2021
Yoshiuchi I.
europepmc   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Space-time distribution of classical scrapie in Italian sheep: assessing the effectiveness of the National Genetic Selection Plan. [PDF]

Vet Res
Desiato R, Desiato R, Ingravalle F, Bertolini S, Aiassa E, Barzanti P, Perrotta MG, Catelan D, Ru G.   +8 more
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Effect of Divergent Genetic Selection for Growth on Spawning Quality in Gilthead Seabream (<i>Sparus aurata</i>). [PDF]

Animals (Basel)
Pérez-García C, Lorenzo-Felipe Á, Ferosekhan S, Shin HS, León-Bernabeu S, Izquierdo M, Montero D, Ginés R, Afonso-López JM, Zamorano MJ.   +9 more
europepmc   +1 more source

Genetic selection modulates feeding behavior of group-housed pigs exposed to daily cyclic high ambient temperatures. [PDF]

PLoS One, 2022
Fraga AZ, Hauschild L, Henrique Reis Furtado Campos P, Valk M, Zava Bello D, Kipper M, Andretta I.   +6 more
europepmc   +1 more source